Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study
Abstract This study aims to investigate the impact of cerebral white matter lesions (CWMLs) on auditory, speech, and non-verbal cognitive (NVC) outcomes following cochlear implantation (CI) in children with prelingually sensorineural deafness (PLSND) and to identify prognostic factors for these doma...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-01158-0 |
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| author | Hejie Li Wei Tang Ting Li Shanhong Wang Hui Li Muqin Yun Jing Xu Weilin Tan Xiaoxia Jin Hairui Huang Hongyan Li Yuanlin Teng Hongzheng Tian Shimin Zong Hongjun Xiao |
| author_facet | Hejie Li Wei Tang Ting Li Shanhong Wang Hui Li Muqin Yun Jing Xu Weilin Tan Xiaoxia Jin Hairui Huang Hongyan Li Yuanlin Teng Hongzheng Tian Shimin Zong Hongjun Xiao |
| author_sort | Hejie Li |
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| description | Abstract This study aims to investigate the impact of cerebral white matter lesions (CWMLs) on auditory, speech, and non-verbal cognitive (NVC) outcomes following cochlear implantation (CI) in children with prelingually sensorineural deafness (PLSND) and to identify prognostic factors for these domains. This province-wide retrospective cohort study included PLSND patients with CWMLs undergoing CI, employing propensity score matching for control. Participants were categorized into four groups based on CWMLs severity for auditory, speech, and NVC assessments at various post-CI intervals. Mixed models were used to analyze prognostic factors. In a cohort of 1163 children with PLSND, 15% exhibited CWMLs. CWMLs patients exhibited poorer pre-CI auditory and reduced post-implantation outcomes, correlated with lesion severity. Recovery patterns varied (auditory: rapid-slow; speech: slow-rapid-slow; NVC: rapid-stable), with speech recovery trailing auditory recovery. Greater severity of CWMLs and elevated pre-CI hearing thresholds are risk factors for poorer post-CI auditory and speech outcomes. Conversely, higher income, enhanced pre-CI auditory and NVC capabilities, prolonged rehabilitation, and cesarean delivery are protective factors for these outcomes. Greater severity of CWMLs served as an independent risk factor for post-CI NVC, while cesarean delivery, strong pre-CI speech capabilities, and Advanced Bionics CI device emerged as independent protective factors. This study highlights the importance of incorporating CWMLs severity, perinatal history, and clinical characteristics into preoperative assessments to refine CI candidacy criteria. The identified recovery patterns further guide personalized rehabilitation strategies, contributing to improved long-term outcomes in children with PLSND. |
| format | Article |
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| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-cf83d3ff103f4b22a2bc7db93a80afe12025-08-20T01:49:40ZengNature PortfolioScientific Reports2045-23222025-05-0115111910.1038/s41598-025-01158-0Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective studyHejie Li0Wei Tang1Ting Li2Shanhong Wang3Hui Li4Muqin Yun5Jing Xu6Weilin Tan7Xiaoxia Jin8Hairui Huang9Hongyan Li10Yuanlin Teng11Hongzheng Tian12Shimin Zong13Hongjun Xiao14Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Rehabilitation for Children with Hearing Impairments, Hubei Disabled Persons’ Federation Rehabilitation CenterDepartment of Speech Training, Hubei Deaf Infant Healing CenterWuhan Yimeng Hearing Rehabilitation CenterHuangshi Rehabilitation Center for Persons with DisabilitiesJingzhou Yimeng Hearing and Speech Rehabilitation CenterJingmen Menghuan Children’s Rehabilitation CenterHuanggang Qisheng Hearing and Speech Rehabilitation CenterXianning Hearing and Speech Rehabilitation CenterEnshi Yimeng Hearing and Speech Rehabilitation CenterXiaogan Yide Hearing and Speech Rehabilitation CenterDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract This study aims to investigate the impact of cerebral white matter lesions (CWMLs) on auditory, speech, and non-verbal cognitive (NVC) outcomes following cochlear implantation (CI) in children with prelingually sensorineural deafness (PLSND) and to identify prognostic factors for these domains. This province-wide retrospective cohort study included PLSND patients with CWMLs undergoing CI, employing propensity score matching for control. Participants were categorized into four groups based on CWMLs severity for auditory, speech, and NVC assessments at various post-CI intervals. Mixed models were used to analyze prognostic factors. In a cohort of 1163 children with PLSND, 15% exhibited CWMLs. CWMLs patients exhibited poorer pre-CI auditory and reduced post-implantation outcomes, correlated with lesion severity. Recovery patterns varied (auditory: rapid-slow; speech: slow-rapid-slow; NVC: rapid-stable), with speech recovery trailing auditory recovery. Greater severity of CWMLs and elevated pre-CI hearing thresholds are risk factors for poorer post-CI auditory and speech outcomes. Conversely, higher income, enhanced pre-CI auditory and NVC capabilities, prolonged rehabilitation, and cesarean delivery are protective factors for these outcomes. Greater severity of CWMLs served as an independent risk factor for post-CI NVC, while cesarean delivery, strong pre-CI speech capabilities, and Advanced Bionics CI device emerged as independent protective factors. This study highlights the importance of incorporating CWMLs severity, perinatal history, and clinical characteristics into preoperative assessments to refine CI candidacy criteria. The identified recovery patterns further guide personalized rehabilitation strategies, contributing to improved long-term outcomes in children with PLSND.https://doi.org/10.1038/s41598-025-01158-0Cerebral white matter lesionsPrelingually sensorineural deafnessPrognostic factors |
| spellingShingle | Hejie Li Wei Tang Ting Li Shanhong Wang Hui Li Muqin Yun Jing Xu Weilin Tan Xiaoxia Jin Hairui Huang Hongyan Li Yuanlin Teng Hongzheng Tian Shimin Zong Hongjun Xiao Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study Scientific Reports Cerebral white matter lesions Prelingually sensorineural deafness Prognostic factors |
| title | Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study |
| title_full | Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study |
| title_fullStr | Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study |
| title_full_unstemmed | Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study |
| title_short | Outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation: a multicenter, retrospective study |
| title_sort | outcomes and prognostic factors in prelingually sensorineural deaf children with cerebral white matter lesions following cochlear implantation a multicenter retrospective study |
| topic | Cerebral white matter lesions Prelingually sensorineural deafness Prognostic factors |
| url | https://doi.org/10.1038/s41598-025-01158-0 |
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