Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder
Several classes of antidepressants can induce syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH), thereby causing hyponatremia. Initial symptoms of hyponatremia include neuropsychiatric and gastrointestinal manifestations can mimic depression, especially in elderly people with mul...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2019/4109150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850172332944916480 |
|---|---|
| author | Ching-Fang Sun Yeo-Lin Chen Ying-Hsuan Li Monika Kumaraswamy Ying-Chih Lo Yi-Ting Chen |
| author_facet | Ching-Fang Sun Yeo-Lin Chen Ying-Hsuan Li Monika Kumaraswamy Ying-Chih Lo Yi-Ting Chen |
| author_sort | Ching-Fang Sun |
| collection | DOAJ |
| description | Several classes of antidepressants can induce syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH), thereby causing hyponatremia. Initial symptoms of hyponatremia include neuropsychiatric and gastrointestinal manifestations can mimic depression, especially in elderly people with multiple somatic complaints. Here we present a case of a 68-year-old man with treatment-refractory depression and general anxiety disorder who developed duloxetine-induced hyponatremia. His symptoms of hyponatremia including unsteady gait, dizziness, nausea, general malaise, and poor appetite subsided after discontinuing the offending medication. Our case illustrates that drug-induced SIADH and potential drug-drug interactions should be considered in elderly patients who develop hyponatremia following the initiation of antidepressants. |
| format | Article |
| id | doaj-art-cf821f3fb8594d85a2a10c0cbc409f7d |
| institution | OA Journals |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-cf821f3fb8594d85a2a10c0cbc409f7d2025-08-20T02:20:06ZengWileyCase Reports in Psychiatry2090-682X2090-68382019-01-01201910.1155/2019/41091504109150Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive DisorderChing-Fang Sun0Yeo-Lin Chen1Ying-Hsuan Li2Monika Kumaraswamy3Ying-Chih Lo4Yi-Ting Chen5College of Medicine, China Medical University, Taichung, TaiwanDepartment of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, TaiwanDepartment of Radiology, China Medical University Hospital, Taichung, TaiwanDivision of Infectious Diseases, University of California San Diego, La Jolla, CA 92093, USADivision of Nephrology, Taichung Veterans General Hospital, Taichung, TaiwanDepartment of Psychiatry & Brain Disease Research Center, China Medical University Hospital, Taichung, TaiwanSeveral classes of antidepressants can induce syndrome of inappropriate antidiuretic hormone hypersecretion (SIADH), thereby causing hyponatremia. Initial symptoms of hyponatremia include neuropsychiatric and gastrointestinal manifestations can mimic depression, especially in elderly people with multiple somatic complaints. Here we present a case of a 68-year-old man with treatment-refractory depression and general anxiety disorder who developed duloxetine-induced hyponatremia. His symptoms of hyponatremia including unsteady gait, dizziness, nausea, general malaise, and poor appetite subsided after discontinuing the offending medication. Our case illustrates that drug-induced SIADH and potential drug-drug interactions should be considered in elderly patients who develop hyponatremia following the initiation of antidepressants.http://dx.doi.org/10.1155/2019/4109150 |
| spellingShingle | Ching-Fang Sun Yeo-Lin Chen Ying-Hsuan Li Monika Kumaraswamy Ying-Chih Lo Yi-Ting Chen Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder Case Reports in Psychiatry |
| title | Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder |
| title_full | Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder |
| title_fullStr | Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder |
| title_full_unstemmed | Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder |
| title_short | Duloxetine-Induced Hyponatremia in an Elderly Male Patient with Treatment-Refractory Major Depressive Disorder |
| title_sort | duloxetine induced hyponatremia in an elderly male patient with treatment refractory major depressive disorder |
| url | http://dx.doi.org/10.1155/2019/4109150 |
| work_keys_str_mv | AT chingfangsun duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder AT yeolinchen duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder AT yinghsuanli duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder AT monikakumaraswamy duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder AT yingchihlo duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder AT yitingchen duloxetineinducedhyponatremiainanelderlymalepatientwithtreatmentrefractorymajordepressivedisorder |