Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease

Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease

<b>Background/Objectives</b>: Brain insulin resistance is a potential causal factor for dementia in Alzheimer’s disease (AD). Insulin-like growth factor-1 (IGF-1), a neurotrophin, plays a key role in central insulin signaling and neuroprotection. Intracerebrovenitricular (ICV) administra...

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Bibliographic Details
Main Authors: Joanna Dunacka, Beata Grembecka, Irena Majkutewicz, Danuta Wrona
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
IGF-1
insulin signaling
sporadic Alzheimer’s disease
spatial memory
neuroinflammation
amyloid-β
Online Access:https://www.mdpi.com/1424-8247/18/4/527
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