Semaglultide targets Spp1+ microglia/macrophage to attenuate neuroinflammation following perioperative stroke

Semaglultide targets Spp1+ microglia/macrophage to attenuate neuroinflammation following perioperative stroke

Abstract Peripheral surgery evokes neuroimmune activation in the central nervous system and modulates immune cell polarization in the ischemic brain. However, the phenotypic change of microglia and myeloid cells within post-surgical ischemic brain tissue remain poorly defined. Using an integrated ap...

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Bibliographic Details
Main Authors: Yan Li, Qiuyue Fan, Rui Pang, Ling Cai, Jie Qi, Weijie Chen, Yueman Zhang, Chen Chen, Weifeng Yu, Peiying Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Neuroinflammation
Subjects:
Perioperative ischemic stroke
Spp1+ Mac/MG
Semaglutide
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-025-03465-9
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