Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials
Abstract Progress in living conditions and medical technology have extended the human life span such that population aging, and thus the development of multi‐system degenerative diseases, has become a major problem in many countries. Bone is a metabolically dynamic tissue and bone aging is closely r...
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| Format: | Article |
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Wiley
2025-06-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | https://doi.org/10.1002/ctm2.70350 |
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| author | Qiyue Zhu Menglong Hu Likun Wu Erfan Wei Xingtong Pan Hao Liu Yunsong Liu |
| author_facet | Qiyue Zhu Menglong Hu Likun Wu Erfan Wei Xingtong Pan Hao Liu Yunsong Liu |
| author_sort | Qiyue Zhu |
| collection | DOAJ |
| description | Abstract Progress in living conditions and medical technology have extended the human life span such that population aging, and thus the development of multi‐system degenerative diseases, has become a major problem in many countries. Bone is a metabolically dynamic tissue and bone aging is closely related to a shift in the balance between bone resorption and bone formation. The resulting loss of bone mass and bone mechanical properties in older adults place them at risk of injury and premature death. Cellular senescence occurs in response to endogenous and exogenous stresses that lead to permanent cell cycle arrest and, thus, to tissue degeneration and dysfunction. Senescence in the bone microenvironment, as occurs during aging, induces a decline in bone formation. Research into the treatment of bone aging has therefore focused on the senescence process. This review begins with a summary of the key events in cellular senescence and bone aging and then examines recent progress in the targeting of cellular senescence, both to treat aging‐related bone diseases. Novel therapeutic agents, natural products, and innovative biomedical materials are considered. Our discussion concludes by considering areas of future research. |
| format | Article |
| id | doaj-art-cf6bcf2cd7df42dba88d56e8d90af7c1 |
| institution | DOAJ |
| issn | 2001-1326 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Medicine |
| spelling | doaj-art-cf6bcf2cd7df42dba88d56e8d90af7c12025-08-20T03:23:56ZengWileyClinical and Translational Medicine2001-13262025-06-01156n/an/a10.1002/ctm2.70350Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materialsQiyue Zhu0Menglong Hu1Likun Wu2Erfan Wei3Xingtong Pan4Hao Liu5Yunsong Liu6Department of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaCentral Laboratory Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials Central Laboratory Peking University School and Hospital of Stomatology Haidian District Beijing PR ChinaAbstract Progress in living conditions and medical technology have extended the human life span such that population aging, and thus the development of multi‐system degenerative diseases, has become a major problem in many countries. Bone is a metabolically dynamic tissue and bone aging is closely related to a shift in the balance between bone resorption and bone formation. The resulting loss of bone mass and bone mechanical properties in older adults place them at risk of injury and premature death. Cellular senescence occurs in response to endogenous and exogenous stresses that lead to permanent cell cycle arrest and, thus, to tissue degeneration and dysfunction. Senescence in the bone microenvironment, as occurs during aging, induces a decline in bone formation. Research into the treatment of bone aging has therefore focused on the senescence process. This review begins with a summary of the key events in cellular senescence and bone aging and then examines recent progress in the targeting of cellular senescence, both to treat aging‐related bone diseases. Novel therapeutic agents, natural products, and innovative biomedical materials are considered. Our discussion concludes by considering areas of future research.https://doi.org/10.1002/ctm2.70350biomedical materialsbone agingcellular senescencemedicinestarget factors |
| spellingShingle | Qiyue Zhu Menglong Hu Likun Wu Erfan Wei Xingtong Pan Hao Liu Yunsong Liu Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials Clinical and Translational Medicine biomedical materials bone aging cellular senescence medicines target factors |
| title | Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials |
| title_full | Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials |
| title_fullStr | Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials |
| title_full_unstemmed | Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials |
| title_short | Antisenescence therapies for age‐related bone loss: Target factors, medicines, biomedical materials |
| title_sort | antisenescence therapies for age related bone loss target factors medicines biomedical materials |
| topic | biomedical materials bone aging cellular senescence medicines target factors |
| url | https://doi.org/10.1002/ctm2.70350 |
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