The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex

Polybrominated diphenyl ethers (PBDEs) are natural products with potent antimicrobial and antineoplastic activity. We have previously shown that the polybrominated diphenyl ether bromoxib (4,5,6-tribromo-2-(2′,4′-dibromophenoxy) phenol), isolated from the marine sponge <i>Dysidea</i> spe...

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Bibliographic Details
Main Authors:	Karina S. Krings, Anastasia Ritchie, Laura Schmitt, Judith Hatzfeld, Gudrun Totzke, Thomas Lenz, María José Mendiburo, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Lisa Müller, Sebastian Wesselborg
Format:	Article
Language:	English
Published:	MDPI AG 2025-02-01
Series:	Marine Drugs
Subjects:	marine sponge-derived natural products polybrominated diphenyl ethers (PBDEs) nucleoporins (NUPs) nuclear pore complex (NPC) nuclear import and export
Online Access:	https://www.mdpi.com/1660-3397/23/3/108
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The Polybrominated Diphenyl Ether Bromoxib Disrupts Nuclear Import and Export by Affecting Nucleoporins of the Nuclear Pore Complex

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