Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome
Abstract Background Leptin (LEP) and adiponectin (ADP) are two significant adipokines that have been related to endocrine disorders of polycystic ovarian syndrome (PCOS). Insulin resistance (IR) is known to be a condition in cells in insulin-sensitive tissues in the body cannot respond normally to t...
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| Language: | English |
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SpringerOpen
2025-08-01
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| Series: | Middle East Fertility Society Journal |
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| Online Access: | https://doi.org/10.1186/s43043-025-00243-8 |
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| author | Sara Sardar Hamad Sardar Nouri Ahmed |
| author_facet | Sara Sardar Hamad Sardar Nouri Ahmed |
| author_sort | Sara Sardar Hamad |
| collection | DOAJ |
| description | Abstract Background Leptin (LEP) and adiponectin (ADP) are two significant adipokines that have been related to endocrine disorders of polycystic ovarian syndrome (PCOS). Insulin resistance (IR) is known to be a condition in cells in insulin-sensitive tissues in the body cannot respond normally to the hormone insulin. Methods This work has been focused on the determination of IR, LEP and ADP levels in overweight women with PCOS patients. A total of 90 women from Shahid Doctor Khalid Hospital (Koya health centers) in Koya-Erbil Governorate have been enrolled to evaluate the difference between insulin, fasting blood glucose (FBG), HbA1C, homeostasis model assessment-insulin resistance (HOMA-IR), LEP, and ADP between groups of PCOS and healthy persons. Results Analysis of variance (ANOVA) test has been found in this work to detect the difference between groups of PCOS (R) in randomly sampling, PCOS (P) in the second day during period cycle and control groups. These data have been shown that the sera levels of LEP, insulin, FBG, and HbA1C were significantly elevated in patients with PCOS groups when compared with healthy individuals. Whereas, serum level of ADP is significantly decreased in patients with PCOS groups compared to control groups. Conclusions The study detected a high level of IR in type PCOS, and a change in adipokines. Accordingly, patients with PCOS should follow up with regular dietary health intake and take foods lowering energy intake with exercise in order to treat PCOS. |
| format | Article |
| id | doaj-art-cf67100ea55a45cfb7f9193012bb23d0 |
| institution | Kabale University |
| issn | 2090-3251 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj-art-cf67100ea55a45cfb7f9193012bb23d02025-08-20T04:03:17ZengSpringerOpenMiddle East Fertility Society Journal2090-32512025-08-013011710.1186/s43043-025-00243-8Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndromeSara Sardar Hamad0Sardar Nouri Ahmed1Department of Chemistry, Faculty of Science and Health, Koya UniversityDepartment of Basic Sciences, College of Medicine, Hawler Medical UniversityAbstract Background Leptin (LEP) and adiponectin (ADP) are two significant adipokines that have been related to endocrine disorders of polycystic ovarian syndrome (PCOS). Insulin resistance (IR) is known to be a condition in cells in insulin-sensitive tissues in the body cannot respond normally to the hormone insulin. Methods This work has been focused on the determination of IR, LEP and ADP levels in overweight women with PCOS patients. A total of 90 women from Shahid Doctor Khalid Hospital (Koya health centers) in Koya-Erbil Governorate have been enrolled to evaluate the difference between insulin, fasting blood glucose (FBG), HbA1C, homeostasis model assessment-insulin resistance (HOMA-IR), LEP, and ADP between groups of PCOS and healthy persons. Results Analysis of variance (ANOVA) test has been found in this work to detect the difference between groups of PCOS (R) in randomly sampling, PCOS (P) in the second day during period cycle and control groups. These data have been shown that the sera levels of LEP, insulin, FBG, and HbA1C were significantly elevated in patients with PCOS groups when compared with healthy individuals. Whereas, serum level of ADP is significantly decreased in patients with PCOS groups compared to control groups. Conclusions The study detected a high level of IR in type PCOS, and a change in adipokines. Accordingly, patients with PCOS should follow up with regular dietary health intake and take foods lowering energy intake with exercise in order to treat PCOS.https://doi.org/10.1186/s43043-025-00243-8AdiponectinInsulinInsulin resistanceLeptinPolycystic ovary syndrome |
| spellingShingle | Sara Sardar Hamad Sardar Nouri Ahmed Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome Middle East Fertility Society Journal Adiponectin Insulin Insulin resistance Leptin Polycystic ovary syndrome |
| title | Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| title_full | Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| title_fullStr | Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| title_full_unstemmed | Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| title_short | Determination of insulin resistance, adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| title_sort | determination of insulin resistance adiponectin and leptin in overweight women with polycystic ovarian syndrome |
| topic | Adiponectin Insulin Insulin resistance Leptin Polycystic ovary syndrome |
| url | https://doi.org/10.1186/s43043-025-00243-8 |
| work_keys_str_mv | AT sarasardarhamad determinationofinsulinresistanceadiponectinandleptininoverweightwomenwithpolycysticovariansyndrome AT sardarnouriahmed determinationofinsulinresistanceadiponectinandleptininoverweightwomenwithpolycysticovariansyndrome |