Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease
Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by protein aggregates, synaptic failure, and cognitive impairment. In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2015/957248 |
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| author | María José Pérez Rodrigo A. Quintanilla |
| author_facet | María José Pérez Rodrigo A. Quintanilla |
| author_sort | María José Pérez |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by protein aggregates, synaptic failure, and cognitive impairment. In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. Currently, there is no effective therapy for AD; however several studies have shown that the treatments with the peroxisome proliferators activated receptor-gamma (PPARγ) agonists known as thiazolidinedione drugs (TZDs), like rosiglitazone and pioglitazone, attenuate neurodegeneration and improve cognition in mouse models and patients with mild-to-moderate AD. Furthermore, studies on animal models have shown that TZDs inhibit neuroinflammation, facilitate amyloid-β plaque clearance, enhance mitochondrial function, improve synaptic plasticity, and, more recently, attenuate tau hyperphosphorylation. How TZDs may improve or reduce these pathologic signs of AD and what the mechanisms and the implicated pathways in which these drugs work are are questions that remain to be answered. However, in this review, we will discuss several cellular targets, in which TZDs can be acting against the neurodegeneration. |
| format | Article |
| id | doaj-art-cf65fd85edeb4b53aa4569674832773b |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-cf65fd85edeb4b53aa4569674832773b2025-02-03T06:13:58ZengWileyPPAR Research1687-47571687-47652015-01-01201510.1155/2015/957248957248Therapeutic Actions of the Thiazolidinediones in Alzheimer’s DiseaseMaría José Pérez0Rodrigo A. Quintanilla1Laboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, San Miguel, 8900000 Santiago, ChileLaboratory of Neurodegenerative Diseases, Centro de Investigación Biomédica, Universidad Autónoma de Chile, San Miguel, 8900000 Santiago, ChileAlzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by protein aggregates, synaptic failure, and cognitive impairment. In the AD brain is common to observe the accumulation of senile plaques formed by amyloid-beta (Aβ) peptide and the neurofibrillary tangles composed of modified tau protein, which both lead to cellular damage and progressive neurodegeneration. Currently, there is no effective therapy for AD; however several studies have shown that the treatments with the peroxisome proliferators activated receptor-gamma (PPARγ) agonists known as thiazolidinedione drugs (TZDs), like rosiglitazone and pioglitazone, attenuate neurodegeneration and improve cognition in mouse models and patients with mild-to-moderate AD. Furthermore, studies on animal models have shown that TZDs inhibit neuroinflammation, facilitate amyloid-β plaque clearance, enhance mitochondrial function, improve synaptic plasticity, and, more recently, attenuate tau hyperphosphorylation. How TZDs may improve or reduce these pathologic signs of AD and what the mechanisms and the implicated pathways in which these drugs work are are questions that remain to be answered. However, in this review, we will discuss several cellular targets, in which TZDs can be acting against the neurodegeneration.http://dx.doi.org/10.1155/2015/957248 |
| spellingShingle | María José Pérez Rodrigo A. Quintanilla Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease PPAR Research |
| title | Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease |
| title_full | Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease |
| title_fullStr | Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease |
| title_full_unstemmed | Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease |
| title_short | Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease |
| title_sort | therapeutic actions of the thiazolidinediones in alzheimer s disease |
| url | http://dx.doi.org/10.1155/2015/957248 |
| work_keys_str_mv | AT mariajoseperez therapeuticactionsofthethiazolidinedionesinalzheimersdisease AT rodrigoaquintanilla therapeuticactionsofthethiazolidinedionesinalzheimersdisease |