Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ t...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/210506 |
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| _version_ | 1832562639229681664 |
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| author | Paulina Ruiz Paula Maldonado Yessia Hidalgo Alejandra Gleisner Daniela Sauma Cinthia Silva Juan Jose Saez Sarah Nuñez Mario Rosemblatt Maria Rosa Bono |
| author_facet | Paulina Ruiz Paula Maldonado Yessia Hidalgo Alejandra Gleisner Daniela Sauma Cinthia Silva Juan Jose Saez Sarah Nuñez Mario Rosemblatt Maria Rosa Bono |
| author_sort | Paulina Ruiz |
| collection | DOAJ |
| description | One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance. |
| format | Article |
| id | doaj-art-cf65614cec564f8ab1dcb799f6bbe2f9 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-cf65614cec564f8ab1dcb799f6bbe2f92025-02-03T01:22:15ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/210506210506Transplant Tolerance: New Insights and Strategies for Long-Term Allograft AcceptancePaulina Ruiz0Paula Maldonado1Yessia Hidalgo2Alejandra Gleisner3Daniela Sauma4Cinthia Silva5Juan Jose Saez6Sarah Nuñez7Mario Rosemblatt8Maria Rosa Bono9Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileDepartamento de Biologia, Facultad de Ciencias, Universidad de Chile, 7800024 Santiago, ChileOne of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance.http://dx.doi.org/10.1155/2013/210506 |
| spellingShingle | Paulina Ruiz Paula Maldonado Yessia Hidalgo Alejandra Gleisner Daniela Sauma Cinthia Silva Juan Jose Saez Sarah Nuñez Mario Rosemblatt Maria Rosa Bono Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance Clinical and Developmental Immunology |
| title | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
| title_full | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
| title_fullStr | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
| title_full_unstemmed | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
| title_short | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
| title_sort | transplant tolerance new insights and strategies for long term allograft acceptance |
| url | http://dx.doi.org/10.1155/2013/210506 |
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