Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report
The overlap of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome (SJS) caused by antituberculosis drugs represents an extremely rare event. This situation can manifest between 2 and 8 weeks after the first exposure to the medication. The overlap of these cond...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | Therapeutic Advances in Drug Safety |
| Online Access: | https://doi.org/10.1177/20420986241312484 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587317830746112 |
|---|---|
| author | Cristian Morán-Mariños Felix Llanos-Tejada Rebeca Huamani-Llantoy Capriny Bernal-Turpo Kimberly López-Pilco Alex Ventura-Leon Renato Casanova-Mendoza |
| author_facet | Cristian Morán-Mariños Felix Llanos-Tejada Rebeca Huamani-Llantoy Capriny Bernal-Turpo Kimberly López-Pilco Alex Ventura-Leon Renato Casanova-Mendoza |
| author_sort | Cristian Morán-Mariños |
| collection | DOAJ |
| description | The overlap of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome (SJS) caused by antituberculosis drugs represents an extremely rare event. This situation can manifest between 2 and 8 weeks after the first exposure to the medication. The overlap of these conditions can lead to atypical clinical manifestations, thus complicating the early diagnosis and the implementation of early treatment. This report describes the case of a patient who developed the DRESS/SJS overlap 35 days after starting antituberculosis treatment. The patient experienced severe skin and systemic involvement, a situation that required her admission and monitoring in the intensive care unit. From our experience with this case, we conclude the importance of an accurate and timely diagnosis using validated scoring systems such as RegiSCAR to confirm the clinical diagnosis of DRESS/SJS and ALDEN to assess the likelihood of drug causality. Timely intervention with corticosteroids plays a key role in moderating the exaggerated immune response, helping to alleviate dermatological symptoms and prevent long-term organ damage. In addition, the availability of safe therapeutic alternatives for tuberculosis treatment allows for more effective and safer management in these patients. |
| format | Article |
| id | doaj-art-cf6128447d5145338552a75924ea17d2 |
| institution | Kabale University |
| issn | 2042-0994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Drug Safety |
| spelling | doaj-art-cf6128447d5145338552a75924ea17d22025-01-24T14:03:21ZengSAGE PublishingTherapeutic Advances in Drug Safety2042-09942025-01-011610.1177/20420986241312484Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case reportCristian Morán-MariñosFelix Llanos-TejadaRebeca Huamani-LlantoyCapriny Bernal-TurpoKimberly López-PilcoAlex Ventura-LeonRenato Casanova-MendozaThe overlap of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) and Stevens-Johnson syndrome (SJS) caused by antituberculosis drugs represents an extremely rare event. This situation can manifest between 2 and 8 weeks after the first exposure to the medication. The overlap of these conditions can lead to atypical clinical manifestations, thus complicating the early diagnosis and the implementation of early treatment. This report describes the case of a patient who developed the DRESS/SJS overlap 35 days after starting antituberculosis treatment. The patient experienced severe skin and systemic involvement, a situation that required her admission and monitoring in the intensive care unit. From our experience with this case, we conclude the importance of an accurate and timely diagnosis using validated scoring systems such as RegiSCAR to confirm the clinical diagnosis of DRESS/SJS and ALDEN to assess the likelihood of drug causality. Timely intervention with corticosteroids plays a key role in moderating the exaggerated immune response, helping to alleviate dermatological symptoms and prevent long-term organ damage. In addition, the availability of safe therapeutic alternatives for tuberculosis treatment allows for more effective and safer management in these patients.https://doi.org/10.1177/20420986241312484 |
| spellingShingle | Cristian Morán-Mariños Felix Llanos-Tejada Rebeca Huamani-Llantoy Capriny Bernal-Turpo Kimberly López-Pilco Alex Ventura-Leon Renato Casanova-Mendoza Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report Therapeutic Advances in Drug Safety |
| title | Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report |
| title_full | Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report |
| title_fullStr | Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report |
| title_full_unstemmed | Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report |
| title_short | Overlapping of DRESS and Stevens-Johnson syndrome due to first-line antituberculosis drugs: a case report |
| title_sort | overlapping of dress and stevens johnson syndrome due to first line antituberculosis drugs a case report |
| url | https://doi.org/10.1177/20420986241312484 |
| work_keys_str_mv | AT cristianmoranmarinos overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT felixllanostejada overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT rebecahuamanillantoy overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT caprinybernalturpo overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT kimberlylopezpilco overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT alexventuraleon overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport AT renatocasanovamendoza overlappingofdressandstevensjohnsonsyndromeduetofirstlineantituberculosisdrugsacasereport |