Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

Cognitive deficit is a debilitating complication of sickle cell disease (SCD), with a multifactorial etiopathogenesis. Here we show that neuroinflammation and dysregulation in lipidomics and transcriptomics profiles are major underlying mechanisms of social stress-induced cognitive deficit in SCD. M...

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Bibliographic Details
Main Authors: S’Dravious A. DeVeaux, Sofiya Vyshnya, Katherine Propsom, Oluwabukola T. Gbotosho, Asem S. Singh, Robert Z. Horning, Mihika Sharma, Anil G. Jegga, Liang Niu, Edward A. Botchwey, Hyacinth I. Hyacinth
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Experimental Biology and Medicine
Subjects:
sickle cell disease
neuroinflammation
cognitive function
social stress
minocycline
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2024.10361/full
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