Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy
The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonic...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2012/270383 |
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| author | Songyot Anuchapreeda Yoshinobu Fukumori Siriporn Okonogi Hideki Ichikawa |
| author_facet | Songyot Anuchapreeda Yoshinobu Fukumori Siriporn Okonogi Hideki Ichikawa |
| author_sort | Songyot Anuchapreeda |
| collection | DOAJ |
| description | The aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated L-α-phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47–55 nm, could incorporate 23–28 mg curcumin per 30 mL, and were stable in particle size for 60 days at 4°C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC50 values ranging from 3.5 to 30.1 and 22.2 to 53.7 μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity. |
| format | Article |
| id | doaj-art-cf59895ff7d14ccdb99edaf2a1a1ceae |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-cf59895ff7d14ccdb99edaf2a1a1ceae2025-02-03T01:24:15ZengWileyJournal of Nanotechnology1687-95031687-95112012-01-01201210.1155/2012/270383270383Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer TherapySongyot Anuchapreeda0Yoshinobu Fukumori1Siriporn Okonogi2Hideki Ichikawa3Division of Clinical Microscopy, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Minatojima 1-1-3, Chuo-ku, Kobe 650-8586, JapanDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandFaculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Minatojima 1-1-3, Chuo-ku, Kobe 650-8586, JapanThe aim of this study was to develop a new formulation of a curcumin lipid nanoemulsion having the smallest particle size, the highest loading, and a good physical stability for cancer chemotherapy. Curcumin lipid nanoemulsions were prepared by a modified thin-film hydration method followed by sonication. Soybean oil, hydrogenated L-α-phosphatidylcholine from egg yolk, and cosurfactants were used to formulate the emulsions. The resultant nanoemulsions showed mean particle diameter of 47–55 nm, could incorporate 23–28 mg curcumin per 30 mL, and were stable in particle size for 60 days at 4°C. The cytotoxicity studies of curucumin solution and curcumin-loaded nanoemulsion using B16F10 and leukemic cell lines showed IC50 values ranging from 3.5 to 30.1 and 22.2 to 53.7 μM, respectively. These results demonstrated the successful incorporation of curcumin into lipid nanoemulsion particles with small particle size, high loading capacity, good physical stability, and preserved cytotoxicity.http://dx.doi.org/10.1155/2012/270383 |
| spellingShingle | Songyot Anuchapreeda Yoshinobu Fukumori Siriporn Okonogi Hideki Ichikawa Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy Journal of Nanotechnology |
| title | Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy |
| title_full | Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy |
| title_fullStr | Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy |
| title_full_unstemmed | Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy |
| title_short | Preparation of Lipid Nanoemulsions Incorporating Curcumin for Cancer Therapy |
| title_sort | preparation of lipid nanoemulsions incorporating curcumin for cancer therapy |
| url | http://dx.doi.org/10.1155/2012/270383 |
| work_keys_str_mv | AT songyotanuchapreeda preparationoflipidnanoemulsionsincorporatingcurcuminforcancertherapy AT yoshinobufukumori preparationoflipidnanoemulsionsincorporatingcurcuminforcancertherapy AT siripornokonogi preparationoflipidnanoemulsionsincorporatingcurcuminforcancertherapy AT hidekiichikawa preparationoflipidnanoemulsionsincorporatingcurcuminforcancertherapy |