Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures
As load-bearing components, metallic implants are frequently used for orthopedic prostheses due to their superiority over conventional ceramic and polymeric biomaterials. Metal-based orthopedic implants have been subjected to various fabrication and treatment methods to enhance their biological acti...
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Elsevier
2025-01-01
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| Series: | Applied Surface Science Advances |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266652392400093X |
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| author | Tahir Nawaz Vinod Paul Sidrah Younus Shahbaz Ahmad Mehmet Egilmez Wael Abuzaid Ganjaboy Boltaev Noor Akbar Mustafa Khamis Ghaleb A. Husseini Ali S. Alnaser |
| author_facet | Tahir Nawaz Vinod Paul Sidrah Younus Shahbaz Ahmad Mehmet Egilmez Wael Abuzaid Ganjaboy Boltaev Noor Akbar Mustafa Khamis Ghaleb A. Husseini Ali S. Alnaser |
| author_sort | Tahir Nawaz |
| collection | DOAJ |
| description | As load-bearing components, metallic implants are frequently used for orthopedic prostheses due to their superiority over conventional ceramic and polymeric biomaterials. Metal-based orthopedic implants have been subjected to various fabrication and treatment methods to enhance their biological activities at the host site. Modifying the structure, improving the hydrophilicity, and developing controlled-release drug delivery systems can improve cellular adhesion, proliferation, osseointegration, and differentiation. Ultrafast lasers have recently attracted interest in surface engineering. Laser surface structuring permits the alteration of sample topography, the chemical makeup of the surface, and the material physical properties. This study presents the surface modification of a TiNbZrSn shape memory alloy using a femtosecond laser to produce laser-induced periodic structures with better drug release than that of a pristine sample. We also present the in vitro cell viability and biocompatibility of the alloy system. All samples structured with femtosecond laser exhibited superhydrophilic nature with 0° contact angle. In addition, the laser structured surfaces showed cell viability above 80 % and minimal cytotoxicity towards human keratinocytes. Moreover, a well-defined hydroxyapatite layer developed on the laser structured surface. In general, the laser structuring process and the induced changes on the surface in terms of roughness and oxide formation result in slower drug release (up to 10 %) compared to pristine specimens. |
| format | Article |
| id | doaj-art-cf5802e8278042e69dfc6c4d17a52a29 |
| institution | Kabale University |
| issn | 2666-5239 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Applied Surface Science Advances |
| spelling | doaj-art-cf5802e8278042e69dfc6c4d17a52a292025-01-29T05:02:03ZengElsevierApplied Surface Science Advances2666-52392025-01-0125100665Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structuresTahir Nawaz0Vinod Paul1Sidrah Younus2Shahbaz Ahmad3Mehmet Egilmez4Wael Abuzaid5Ganjaboy Boltaev6Noor Akbar7Mustafa Khamis8Ghaleb A. Husseini9Ali S. Alnaser10Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesDepartment of Physics, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Research Center, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Research Center, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Department of Mechanical Engineering, American University of Sharjah, Sharjah 26666, United Arab Emirates; Corresponding authors.Department of Physics, American University of Sharjah, Sharjah 26666, United Arab EmiratesResearch Institute of Medical and Health Sciences, University of Sharjah, Sharjah 27272, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Research Center, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Department of Biology, Chemistry, and Environmental Sciences, American University of Sharjah, Sharjah 26666, United Arab EmiratesMaterials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Research Center, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Department of Chemical and Biological Engineering, College of Engineering, American University of Sharjah, Sharjah, P.O. Box 26666, United Arab EmiratesDepartment of Physics, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Science and Engineering Program, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Materials Research Center, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates; Corresponding authors.As load-bearing components, metallic implants are frequently used for orthopedic prostheses due to their superiority over conventional ceramic and polymeric biomaterials. Metal-based orthopedic implants have been subjected to various fabrication and treatment methods to enhance their biological activities at the host site. Modifying the structure, improving the hydrophilicity, and developing controlled-release drug delivery systems can improve cellular adhesion, proliferation, osseointegration, and differentiation. Ultrafast lasers have recently attracted interest in surface engineering. Laser surface structuring permits the alteration of sample topography, the chemical makeup of the surface, and the material physical properties. This study presents the surface modification of a TiNbZrSn shape memory alloy using a femtosecond laser to produce laser-induced periodic structures with better drug release than that of a pristine sample. We also present the in vitro cell viability and biocompatibility of the alloy system. All samples structured with femtosecond laser exhibited superhydrophilic nature with 0° contact angle. In addition, the laser structured surfaces showed cell viability above 80 % and minimal cytotoxicity towards human keratinocytes. Moreover, a well-defined hydroxyapatite layer developed on the laser structured surface. In general, the laser structuring process and the induced changes on the surface in terms of roughness and oxide formation result in slower drug release (up to 10 %) compared to pristine specimens.http://www.sciencedirect.com/science/article/pii/S266652392400093XTiNbZr shape memory alloyBiocompatibilityFemtosecond laser structuringDrug release rate |
| spellingShingle | Tahir Nawaz Vinod Paul Sidrah Younus Shahbaz Ahmad Mehmet Egilmez Wael Abuzaid Ganjaboy Boltaev Noor Akbar Mustafa Khamis Ghaleb A. Husseini Ali S. Alnaser Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures Applied Surface Science Advances TiNbZr shape memory alloy Biocompatibility Femtosecond laser structuring Drug release rate |
| title | Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures |
| title_full | Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures |
| title_fullStr | Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures |
| title_full_unstemmed | Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures |
| title_short | Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures |
| title_sort | biocompatibility and drug release kinetics of tinbzrsn femtosecond laser induced superhydrophilic structures |
| topic | TiNbZr shape memory alloy Biocompatibility Femtosecond laser structuring Drug release rate |
| url | http://www.sciencedirect.com/science/article/pii/S266652392400093X |
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