Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article
Abstract Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortiso...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01074-z |
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| author | Syed Faizan Mehdi Muhammad Hamza Qureshi Salman Pervaiz Karishma Kumari Edwin Saji Mahnoor Shah Ahmad Abdullah Kamran Zahoor Hafiza Amna Qadeer Disha Kumari Katari Christine Metz Lopa Mishra Derek LeRoith Kevin Tracey Michael J. Brownstein Jesse Roth |
| author_facet | Syed Faizan Mehdi Muhammad Hamza Qureshi Salman Pervaiz Karishma Kumari Edwin Saji Mahnoor Shah Ahmad Abdullah Kamran Zahoor Hafiza Amna Qadeer Disha Kumari Katari Christine Metz Lopa Mishra Derek LeRoith Kevin Tracey Michael J. Brownstein Jesse Roth |
| author_sort | Syed Faizan Mehdi |
| collection | DOAJ |
| description | Abstract Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. Further research is essential to look into the hormonal changes that occur during sepsis, not only to understand their potential relevance in therapy but also because they may serve as prognostic indicators. |
| format | Article |
| id | doaj-art-cf542909976d4281896b6ebaef986eba |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-cf542909976d4281896b6ebaef986eba2025-01-26T12:38:36ZengBMCMolecular Medicine1528-36582025-01-0131112110.1186/s10020-025-01074-zEndocrine and metabolic alterations in response to systemic inflammation and sepsis: a review articleSyed Faizan Mehdi0Muhammad Hamza Qureshi1Salman Pervaiz2Karishma Kumari3Edwin Saji4Mahnoor Shah5Ahmad Abdullah6Kamran Zahoor7Hafiza Amna Qadeer8Disha Kumari Katari9Christine Metz10Lopa Mishra11Derek LeRoith12Kevin Tracey13Michael J. Brownstein14Jesse Roth15The Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthThe Feinstein Institutes for Medical Research/Northwell HealthDivision of Endocrinology, Diabetes & Bone Disease, Icahn School of Medicine at Mt. SinaiThe Feinstein Institutes for Medical Research/Northwell HealthAzevan Pharmaceuticals Inc.The Feinstein Institutes for Medical Research/Northwell HealthAbstract Severe sepsis is cognate with life threatening multi-organ dysfunction. There is a disturbance in endocrine functions with alterations in several hormonal pathways. It has frequently been linked with dysfunction in the hypothalamic pituitary-adrenal axis (HPA). Increased cortisol or cortisolemia is evident throughout the acute phase, along with changes in the hypothalamic pituitary thyroid (HPT) axis, growth hormone-IGF-1 axis, insulin-glucose axis, leptin, catecholamines, renin angiotensin aldosterone axis, ghrelin, glucagon, hypothalamic pituitary gonadal (HGA) axis, and fibroblast growth factor-21. These changes and metabolic alterations constitute the overall response to infection in sepsis. Further research is essential to look into the hormonal changes that occur during sepsis, not only to understand their potential relevance in therapy but also because they may serve as prognostic indicators.https://doi.org/10.1186/s10020-025-01074-zInflammationSepsisSeptic shockMetabolismHormonesEndocrine |
| spellingShingle | Syed Faizan Mehdi Muhammad Hamza Qureshi Salman Pervaiz Karishma Kumari Edwin Saji Mahnoor Shah Ahmad Abdullah Kamran Zahoor Hafiza Amna Qadeer Disha Kumari Katari Christine Metz Lopa Mishra Derek LeRoith Kevin Tracey Michael J. Brownstein Jesse Roth Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article Molecular Medicine Inflammation Sepsis Septic shock Metabolism Hormones Endocrine |
| title | Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article |
| title_full | Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article |
| title_fullStr | Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article |
| title_full_unstemmed | Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article |
| title_short | Endocrine and metabolic alterations in response to systemic inflammation and sepsis: a review article |
| title_sort | endocrine and metabolic alterations in response to systemic inflammation and sepsis a review article |
| topic | Inflammation Sepsis Septic shock Metabolism Hormones Endocrine |
| url | https://doi.org/10.1186/s10020-025-01074-z |
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