A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen
About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug. While many...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.4061/2011/232435 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | About two thirds of all human breast cancer cases are estrogen receptor positive.
The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor
are or become resistant to this drug. While many mechanisms have been identified for tamoxifen resistance in the lab, at present only a
few have been translated to the clinic. This paper highlights the role in tamoxifen resistance of phosphorylation by different kinases on different
sites of the estrogen receptor. We will discuss the molecular pathways and kinases that are involved in phosphorylation of ERα and how
these affect tamoxifen resistance. Finally, we will elaborate on the clinical translation of these observations and the possibility to predict tamoxifen
responses in patient tumor samples before treatment onset. The findings made originally on the bench may translate into a better and personalized
treatment of breast cancer patients using an old and safe anticancer drug: tamoxifen. |
|---|---|
| ISSN: | 2090-3189 |