Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat
The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severit...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2974304 |
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| author | L. Al Kury M. Smail M. A. Qureshi V. Sydorenko A. Shmygol M. Oz J. Singh F. C. Howarth |
| author_facet | L. Al Kury M. Smail M. A. Qureshi V. Sydorenko A. Shmygol M. Oz J. Singh F. C. Howarth |
| author_sort | L. Al Kury |
| collection | DOAJ |
| description | The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction. |
| format | Article |
| id | doaj-art-cf4e54baf2704919a6e0d8f3f827fbc2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-cf4e54baf2704919a6e0d8f3f827fbc22025-02-03T06:11:38ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/29743042974304Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic RatL. Al Kury0M. Smail1M. A. Qureshi2V. Sydorenko3A. Shmygol4M. Oz5J. Singh6F. C. Howarth7College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAEDepartment of Physiology, College of Medicine & Health Sciences, UAE University, Al Ain, UAEDepartment of Physiology, College of Medicine & Health Sciences, UAE University, Al Ain, UAEDepartment of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, UkraineDepartment of Physiology, College of Medicine & Health Sciences, UAE University, Al Ain, UAEDepartment of Basic Medical Sciences, College of Medicine, Qatar University, Doha, QatarSchool of Forensic & Applied Sciences, University of Central Lancashire, Preston, UKDepartment of Physiology, College of Medicine & Health Sciences, UAE University, Al Ain, UAEThe association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients’ age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.http://dx.doi.org/10.1155/2018/2974304 |
| spellingShingle | L. Al Kury M. Smail M. A. Qureshi V. Sydorenko A. Shmygol M. Oz J. Singh F. C. Howarth Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat Journal of Diabetes Research |
| title | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat |
| title_full | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat |
| title_fullStr | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat |
| title_full_unstemmed | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat |
| title_short | Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 Diabetic Rat |
| title_sort | calcium signaling in the ventricular myocardium of the goto kakizaki type 2 diabetic rat |
| url | http://dx.doi.org/10.1155/2018/2974304 |
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