Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report
ABSTRACT Lazertinib is a third‐generation epidermal growth factor receptor tyrosine kinase inhibitor effective in patients with non‐small cell lung cancer. Although generally well tolerated, this case report presents a rare occurrence of common terminology criteria for adverse events grade 3 rhabdom...
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Wiley
2025-02-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.70105 |
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| author | Seunghun Lee Juwhan Choi Sung Yong Lee |
| author_facet | Seunghun Lee Juwhan Choi Sung Yong Lee |
| author_sort | Seunghun Lee |
| collection | DOAJ |
| description | ABSTRACT Lazertinib is a third‐generation epidermal growth factor receptor tyrosine kinase inhibitor effective in patients with non‐small cell lung cancer. Although generally well tolerated, this case report presents a rare occurrence of common terminology criteria for adverse events grade 3 rhabdomyolysis in a 69‐year‐old Korean woman after taking lazertinib. The patient exhibited general weakness and tea‐coloured urine with elevated levels of creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), serum myoglobin and hyperkalemia. Lazertinib was temporarily discontinued, and urine alkalization was initiated. After the patient's condition improved, lazertinib was restarted at a reduced dose (80 mg) without any adverse effects. This case highlights the importance of assessing CPK and LDH levels in patients undergoing treatment with lazertinib, particularly in those with myalgia and elevated AST levels. Further studies are required to clarify the mechanisms underlying lazertinib‐induced rhabdomyolysis. |
| format | Article |
| id | doaj-art-cf452bf031b74c5a8aa4d7613d7fc346 |
| institution | OA Journals |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-cf452bf031b74c5a8aa4d7613d7fc3462025-08-20T02:07:13ZengWileyRespirology Case Reports2051-33802025-02-01132n/an/a10.1002/rcr2.70105Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case ReportSeunghun Lee0Juwhan Choi1Sung Yong Lee2Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine Seoul Republic of KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine Seoul Republic of KoreaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital Korea University College of Medicine Seoul Republic of KoreaABSTRACT Lazertinib is a third‐generation epidermal growth factor receptor tyrosine kinase inhibitor effective in patients with non‐small cell lung cancer. Although generally well tolerated, this case report presents a rare occurrence of common terminology criteria for adverse events grade 3 rhabdomyolysis in a 69‐year‐old Korean woman after taking lazertinib. The patient exhibited general weakness and tea‐coloured urine with elevated levels of creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), serum myoglobin and hyperkalemia. Lazertinib was temporarily discontinued, and urine alkalization was initiated. After the patient's condition improved, lazertinib was restarted at a reduced dose (80 mg) without any adverse effects. This case highlights the importance of assessing CPK and LDH levels in patients undergoing treatment with lazertinib, particularly in those with myalgia and elevated AST levels. Further studies are required to clarify the mechanisms underlying lazertinib‐induced rhabdomyolysis.https://doi.org/10.1002/rcr2.70105case reportlazertinibnon‐small cell lung cancerrhabdomyolysis |
| spellingShingle | Seunghun Lee Juwhan Choi Sung Yong Lee Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report Respirology Case Reports case report lazertinib non‐small cell lung cancer rhabdomyolysis |
| title | Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report |
| title_full | Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report |
| title_fullStr | Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report |
| title_full_unstemmed | Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report |
| title_short | Lazertinib‐Induced Rhabdomyolysis in a Patient With Non‐Small Cell Lung Cancer: A Case Report |
| title_sort | lazertinib induced rhabdomyolysis in a patient with non small cell lung cancer a case report |
| topic | case report lazertinib non‐small cell lung cancer rhabdomyolysis |
| url | https://doi.org/10.1002/rcr2.70105 |
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