Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response
The adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection through recognition of tumor antigens and direct killing of transformed cells. In growing t...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8941260 |
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| author | John Reiser Arnob Banerjee |
| author_facet | John Reiser Arnob Banerjee |
| author_sort | John Reiser |
| collection | DOAJ |
| description | The adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection through recognition of tumor antigens and direct killing of transformed cells. In growing tumors, TILs are often functionally impaired as a result of interaction with, or signals from, transformed cells and the tumor microenvironment. These interactions and signals can lead to transcriptional, functional, and phenotypic changes in TILs that diminish the host’s ability to eradicate the tumor. In addition to effector and memory CD8+ T cells, populations described as exhausted, anergic, senescent, and regulatory CD8+ T cells have been observed in clinical and basic studies of antitumor immune responses. In the context of antitumor immunity, these CD8+ T cell subsets remain poorly characterized in terms of fate-specific biomarkers and transcription factor profiles. Here we discuss the current characterization of CD8+ T cell fates in antitumor immune responses and discuss recent insights into how signals in the tumor microenvironment influence TIL transcriptional networks to promote CD8+ T cell dysfunction. |
| format | Article |
| id | doaj-art-cf3ed0d74f0a47e69da6230333707838 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-cf3ed0d74f0a47e69da62303337078382025-02-03T05:59:51ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/89412608941260Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune ResponseJohn Reiser0Arnob Banerjee1University of Maryland School of Medicine, 20 Penn Street, Building HSFII, Lab No. S109, Baltimore, MD 21230, USAUniversity of Maryland School of Medicine, 20 Penn Street, Building HSFII, Lab No. S109, Baltimore, MD 21230, USAThe adaptive immune system plays a pivotal role in the host’s ability to mount an effective, antigen-specific immune response against tumors. CD8+ tumor-infiltrating lymphocytes (TILs) mediate tumor rejection through recognition of tumor antigens and direct killing of transformed cells. In growing tumors, TILs are often functionally impaired as a result of interaction with, or signals from, transformed cells and the tumor microenvironment. These interactions and signals can lead to transcriptional, functional, and phenotypic changes in TILs that diminish the host’s ability to eradicate the tumor. In addition to effector and memory CD8+ T cells, populations described as exhausted, anergic, senescent, and regulatory CD8+ T cells have been observed in clinical and basic studies of antitumor immune responses. In the context of antitumor immunity, these CD8+ T cell subsets remain poorly characterized in terms of fate-specific biomarkers and transcription factor profiles. Here we discuss the current characterization of CD8+ T cell fates in antitumor immune responses and discuss recent insights into how signals in the tumor microenvironment influence TIL transcriptional networks to promote CD8+ T cell dysfunction.http://dx.doi.org/10.1155/2016/8941260 |
| spellingShingle | John Reiser Arnob Banerjee Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response Journal of Immunology Research |
| title | Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response |
| title_full | Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response |
| title_fullStr | Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response |
| title_full_unstemmed | Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response |
| title_short | Effector, Memory, and Dysfunctional CD8+ T Cell Fates in the Antitumor Immune Response |
| title_sort | effector memory and dysfunctional cd8 t cell fates in the antitumor immune response |
| url | http://dx.doi.org/10.1155/2016/8941260 |
| work_keys_str_mv | AT johnreiser effectormemoryanddysfunctionalcd8tcellfatesintheantitumorimmuneresponse AT arnobbanerjee effectormemoryanddysfunctionalcd8tcellfatesintheantitumorimmuneresponse |