Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes
Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. This study investigated the use of cocoliposomes fo...
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| Format: | Article |
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De Gruyter
2024-12-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2024-0122 |
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| author | Hudiyanti Dwi Hidayati Salma Nur Siahaan Parsaoran Ngadiwiyana Ngadiwiyana Nur Abidin Sari Ratna Indria Amalia Indrian Rizka Christa Sherllyn Meida Patrechia Amanda Chindy Maharani Adinda Eka |
| author_facet | Hudiyanti Dwi Hidayati Salma Nur Siahaan Parsaoran Ngadiwiyana Ngadiwiyana Nur Abidin Sari Ratna Indria Amalia Indrian Rizka Christa Sherllyn Meida Patrechia Amanda Chindy Maharani Adinda Eka |
| author_sort | Hudiyanti Dwi |
| collection | DOAJ |
| description | Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. This study investigated the use of cocoliposomes for encapsulating VEA (VEACL). The cocoliposomes consisted of coconut phospholipids (CocoPLs) and cholesterol (Chol). Several parameters, such as functional groups, transition temperature, encapsulation efficiency (EE), release profile, particle size, polydispersity index, and zeta potential, were analyzed to evaluate the impact of cholesterol inclusion on the cocoliposome membrane. The results show that the Fourier transform infrared spectra of VEACL do not exhibit any new, distinct peaks that differ from the peaks of its constituent composition. Therefore, it confirmed that no chemical reactions occurred during the manufacturing of VEACL. Cholesterol in the system raises the transition temperature of phospholipids and enhances the stability of VEACL. The EE remains above 80% despite a 20% increase in cholesterol levels. The release rate of VEA from cocoliposomes was slower with VEACL–20%Chol compared to VEACL–0%Chol. The cholesterol level leads to a decrease in particle size and an increase in the negative zeta potential of the cocoliposomes. Data show that cocoliposomes are effective carriers for VEA encapsulation. |
| format | Article |
| id | doaj-art-cf3b43de2405450b8ce16aa9fcc14d3a |
| institution | Kabale University |
| issn | 2391-5420 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj-art-cf3b43de2405450b8ce16aa9fcc14d3a2025-01-20T11:08:20ZengDe GruyterOpen Chemistry2391-54202024-12-012213122110.1515/chem-2024-0122Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomesHudiyanti Dwi0Hidayati Salma Nur1Siahaan Parsaoran2Ngadiwiyana Ngadiwiyana3Nur Abidin4Sari Ratna Indria5Amalia Indrian Rizka6Christa Sherllyn Meida7Patrechia Amanda Chindy8Maharani Adinda Eka9Department of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaChemistry Program, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaDepartment of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaDepartment of Chemistry, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaResearch Center for Fishery, National Research and Innovation Agency, Bogor, IndonesiaResearch Center for Fishery, National Research and Innovation Agency, Bogor, IndonesiaResearch Center for Fishery, National Research and Innovation Agency, Bogor, IndonesiaChemistry Program, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaChemistry Program, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaChemistry Program, Faculty of Sciences and Mathematics, Diponegoro University, Semarang, 50275, IndonesiaVitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. This study investigated the use of cocoliposomes for encapsulating VEA (VEACL). The cocoliposomes consisted of coconut phospholipids (CocoPLs) and cholesterol (Chol). Several parameters, such as functional groups, transition temperature, encapsulation efficiency (EE), release profile, particle size, polydispersity index, and zeta potential, were analyzed to evaluate the impact of cholesterol inclusion on the cocoliposome membrane. The results show that the Fourier transform infrared spectra of VEACL do not exhibit any new, distinct peaks that differ from the peaks of its constituent composition. Therefore, it confirmed that no chemical reactions occurred during the manufacturing of VEACL. Cholesterol in the system raises the transition temperature of phospholipids and enhances the stability of VEACL. The EE remains above 80% despite a 20% increase in cholesterol levels. The release rate of VEA from cocoliposomes was slower with VEACL–20%Chol compared to VEACL–0%Chol. The cholesterol level leads to a decrease in particle size and an increase in the negative zeta potential of the cocoliposomes. Data show that cocoliposomes are effective carriers for VEA encapsulation.https://doi.org/10.1515/chem-2024-0122encapsulation efficiencydifferential scanning calorimeterrelease rateparticle sizezeta potentialthermal analysis |
| spellingShingle | Hudiyanti Dwi Hidayati Salma Nur Siahaan Parsaoran Ngadiwiyana Ngadiwiyana Nur Abidin Sari Ratna Indria Amalia Indrian Rizka Christa Sherllyn Meida Patrechia Amanda Chindy Maharani Adinda Eka Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes Open Chemistry encapsulation efficiency differential scanning calorimeter release rate particle size zeta potential thermal analysis |
| title | Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes |
| title_full | Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes |
| title_fullStr | Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes |
| title_full_unstemmed | Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes |
| title_short | Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes |
| title_sort | impact of cholesterol in encapsulated vitamin e acetate within cocoliposomes |
| topic | encapsulation efficiency differential scanning calorimeter release rate particle size zeta potential thermal analysis |
| url | https://doi.org/10.1515/chem-2024-0122 |
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