Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy
Radiation therapy (RT) is the standard of care for cases of superior vena cava (SVC) syndrome secondary to metastatic adenopathy. Histologies vary in radiosensitivity and response time, making alternative therapies such as chemotherapy and/or intravenous stenting preferable alternative options for c...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/513685 |
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| author | Nishan Bingham H. James Wallace III Joanne Monterroso Claire Verschraegen Brenda L. Waters Christopher J. Anker |
| author_facet | Nishan Bingham H. James Wallace III Joanne Monterroso Claire Verschraegen Brenda L. Waters Christopher J. Anker |
| author_sort | Nishan Bingham |
| collection | DOAJ |
| description | Radiation therapy (RT) is the standard of care for cases of superior vena cava (SVC) syndrome secondary to metastatic adenopathy. Histologies vary in radiosensitivity and response time, making alternative therapies such as chemotherapy and/or intravenous stenting preferable alternative options for certain diagnoses. Metastatic urothelial carcinoma is a particularly rare cause of SVC syndrome with only 3 cases reported in the literature. Consequently, optimal management remains challenging, particularly in cases of high tumor burden. Here we present a case of highly advanced metastatic urothelial cancer with SVC syndrome and tracheal compression. The patient started urgent RT but expired midway through her treatment course due to systemic progression of disease, requiring SVC and tracheal stenting. The authors review the literature including discussion of the few other known cases of SVC syndrome due to urothelial carcinoma and a review of this histology’s response to RT. This experience suggests, that in cases of SVC syndrome with widespread advanced disease, stenting and chemotherapy with or without RT may be the most important initial treatment plan, depending on goals of care. |
| format | Article |
| id | doaj-art-cf397ddccaf24e7b8a67f0789a2ceee3 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-cf397ddccaf24e7b8a67f0789a2ceee32025-02-03T06:01:45ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/513685513685Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation TherapyNishan Bingham0H. James Wallace III1Joanne Monterroso2Claire Verschraegen3Brenda L. Waters4Christopher J. Anker5University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USADivision of Radiation Oncology, University of Vermont Cancer Center, 111 Colchester Avenue, Mailstop 301SH2, Burlington, VT 05401, USADivision of Hematology Oncology, University of Vermont Cancer Center, 89 Beaumont Avenue, Suite E-214, Burlington, VT 05405, USADivision of Hematology Oncology, University of Vermont Cancer Center, 89 Beaumont Avenue, Suite E-214, Burlington, VT 05405, USADepartment of Pathology and Laboratory Medicine, University of Vermont Medical Center, 111 Colchester Avenue Main Campus, East Pavilion, Burlington, VT 05401, USADivision of Radiation Oncology, University of Vermont Cancer Center, 111 Colchester Avenue, Mailstop 301SH2, Burlington, VT 05401, USARadiation therapy (RT) is the standard of care for cases of superior vena cava (SVC) syndrome secondary to metastatic adenopathy. Histologies vary in radiosensitivity and response time, making alternative therapies such as chemotherapy and/or intravenous stenting preferable alternative options for certain diagnoses. Metastatic urothelial carcinoma is a particularly rare cause of SVC syndrome with only 3 cases reported in the literature. Consequently, optimal management remains challenging, particularly in cases of high tumor burden. Here we present a case of highly advanced metastatic urothelial cancer with SVC syndrome and tracheal compression. The patient started urgent RT but expired midway through her treatment course due to systemic progression of disease, requiring SVC and tracheal stenting. The authors review the literature including discussion of the few other known cases of SVC syndrome due to urothelial carcinoma and a review of this histology’s response to RT. This experience suggests, that in cases of SVC syndrome with widespread advanced disease, stenting and chemotherapy with or without RT may be the most important initial treatment plan, depending on goals of care.http://dx.doi.org/10.1155/2015/513685 |
| spellingShingle | Nishan Bingham H. James Wallace III Joanne Monterroso Claire Verschraegen Brenda L. Waters Christopher J. Anker Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy Case Reports in Oncological Medicine |
| title | Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy |
| title_full | Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy |
| title_fullStr | Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy |
| title_full_unstemmed | Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy |
| title_short | Urothelial Superior Vena Cava Syndrome with Limited Response to Radiation Therapy |
| title_sort | urothelial superior vena cava syndrome with limited response to radiation therapy |
| url | http://dx.doi.org/10.1155/2015/513685 |
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