Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation

Sirtuin1 Suppresses Calcium Oxalate Nephropathy via Inhibition of Renal Proximal Tubular Cell Ferroptosis Through PGC‐1α‐mediated Transcriptional Coactivation

Abstract Calcium oxalate (CaOx) crystals induce renal tubular epithelial cell injury and subsequent nephropathy. However, the underlying mechanisms remain unclear. In the present study, single‐cell transcriptome sequencing is performed on kidney samples from mice with CaOx nephrocalcinosis. Renal pr...

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Main Authors: Chen Duan, Bo Li, Haoran Liu, Yangjun Zhang, Xiangyang Yao, Kai Liu, Xiaoliang Wu, Xiongmin Mao, Huahui Wu, Zhenzhen Xu, Yahua Zhong, Zhiquan Hu, Yan Gong, Hua Xu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
crystal nephropathy
ferroptosis
PGC‐1α
renal proximal tubular cells
Sirt1
Online Access:https://doi.org/10.1002/advs.202408945
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