β-adrenergic signaling modulates breast cancer cell mechanical behaviors through a RhoA-ROCK-myosin II axis

β-adrenergic signaling modulates breast cancer cell mechanical behaviors through a RhoA-ROCK-myosin II axis

Summary: The ability of cancer cells to deform and generate force is implicated in metastasis. We previously showed that β-adrenergic agonists increase cancer cell stiffness, which was associated with enhanced motility and invasion. Here, we investigate how β-adrenoceptor (βAR) activation alters the...

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Bibliographic Details
Main Authors: Tae-Hyung Kim, Minh-Tam Tran Le, Mijung Oh, Esteban Vazquez-Hidalgo, Bryanna Chavez, Donald M. Lamkin, Alexander Abdou, Xing Haw Marvin Tan, Alexei Christodoulides, Carly M. Farris, Changhoon Lee, Pei-Yu Chiou, Erica K. Sloan, Parag Katira, Amy C. Rowat
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:iScience
Subjects:
Mechanobiology
Cell biology
Functional aspects of cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422500937X
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