Low agreement and frequent invalid controls in two SARS-CoV-2 T-cell assays in people with compromised immune function.

Low agreement and frequent invalid controls in two SARS-CoV-2 T-cell assays in people with compromised immune function.

T-cell response plays an important role in SARS-CoV-2 immunogenicity. For people living with HIV (PWH) and solid organ transplant (SOT) recipients there is limited evidence on the reliability of commercially available T-cell tests. We assessed 173 blood samples from 81 participants (62 samples from...

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Main Authors: Annette Audigé, Alain Amstutz, Macé M Schuurmans, Patrizia Amico, Dominique L Braun, Marcel P Stoeckle, Barbara Hasse, René Hage, Dominik Damm, Michael Tamm, Nicolas J Mueller, Huldrych F Günthard, Michael T Koller, Christof M Schönenberger, Alexandra Griessbach, Niklaus D Labhardt, Roger D Kouyos, Alexandra Trkola, Michael Huber, Katharina Kusejko, Heiner C Bucher, Irene A Abela, Matthias Briel, Frédérique Chammartin, Benjamin Speich, Swiss HIV Cohort Study, and the Swiss Transplant Cohort Study
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0317965
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