Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway
Hepatic ischemia/reperfusion injury (HIRI) is a common complication of liver surgery requiring hepatic disconnection, such as hepatectomy and liver transplantation. The aim of this study was to investigate the effects of cordycepin on HIRI and to elucidate the underlying mechanisms. Balb/c mice were...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2022/5676256 |
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| author | Jiameng Ding null WenjuanYang Yuhui Jiang Jie Ji Jie Zhang Liwei Wu Jiao Feng Yuanyuan Zheng Yan Li Ziqi Cheng Qiang Yu Jianye Wu Jingjing Li Kan Chen Chuanyong Guo |
| author_facet | Jiameng Ding null WenjuanYang Yuhui Jiang Jie Ji Jie Zhang Liwei Wu Jiao Feng Yuanyuan Zheng Yan Li Ziqi Cheng Qiang Yu Jianye Wu Jingjing Li Kan Chen Chuanyong Guo |
| author_sort | Jiameng Ding |
| collection | DOAJ |
| description | Hepatic ischemia/reperfusion injury (HIRI) is a common complication of liver surgery requiring hepatic disconnection, such as hepatectomy and liver transplantation. The aim of this study was to investigate the effects of cordycepin on HIRI and to elucidate the underlying mechanisms. Balb/c mice were randomly divided into six groups: a normal control group, sham group, H-cordycepin group, HIRI group, L-cordycepin (25 mg/kg) + HIRI group, and H-cordycepin (50 mg/kg) + HIRI group. Mice were subjected to I/R, and cordycepin was intragastrically administered for seven consecutive days before surgery. Orbital blood and liver specimens were collected at 6 and 24 h after HIRI. Serum levels of ALT and AST were decreased in the cordycepin pretreatment groups. Notably, cordycepin attenuated the inflammatory response and the production of proapoptosis proteins, while increasing expression of antiapoptosis proteins and decreasing expression of autophagy-linked proteins. Furthermore, cordycepin inhibited activation of the MAPK/NF-κB signaling pathway. Collectively, these results indicate that cordycepin pretreatment ameliorated hepatocyte injury caused by HIRI. As compared with the HIRI group, cordycepin pretreatment mitigated the inflammatory response and inhibited apoptosis and autophagy via regulation of the MAPK/NF-κB signaling pathway. |
| format | Article |
| id | doaj-art-cf2cb88ab0604f2c9b166dd5362a52d9 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cf2cb88ab0604f2c9b166dd5362a52d92025-02-03T00:59:37ZengWileyMediators of Inflammation1466-18612022-01-01202210.1155/2022/5676256Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB PathwayJiameng Ding0null WenjuanYang1Yuhui Jiang2Jie Ji3Jie Zhang4Liwei Wu5Jiao Feng6Yuanyuan Zheng7Yan Li8Ziqi Cheng9Qiang Yu10Jianye Wu11Jingjing Li12Kan Chen13Chuanyong Guo14Department of GastroenterologyDepartment of EmergencyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyHepatic ischemia/reperfusion injury (HIRI) is a common complication of liver surgery requiring hepatic disconnection, such as hepatectomy and liver transplantation. The aim of this study was to investigate the effects of cordycepin on HIRI and to elucidate the underlying mechanisms. Balb/c mice were randomly divided into six groups: a normal control group, sham group, H-cordycepin group, HIRI group, L-cordycepin (25 mg/kg) + HIRI group, and H-cordycepin (50 mg/kg) + HIRI group. Mice were subjected to I/R, and cordycepin was intragastrically administered for seven consecutive days before surgery. Orbital blood and liver specimens were collected at 6 and 24 h after HIRI. Serum levels of ALT and AST were decreased in the cordycepin pretreatment groups. Notably, cordycepin attenuated the inflammatory response and the production of proapoptosis proteins, while increasing expression of antiapoptosis proteins and decreasing expression of autophagy-linked proteins. Furthermore, cordycepin inhibited activation of the MAPK/NF-κB signaling pathway. Collectively, these results indicate that cordycepin pretreatment ameliorated hepatocyte injury caused by HIRI. As compared with the HIRI group, cordycepin pretreatment mitigated the inflammatory response and inhibited apoptosis and autophagy via regulation of the MAPK/NF-κB signaling pathway.http://dx.doi.org/10.1155/2022/5676256 |
| spellingShingle | Jiameng Ding null WenjuanYang Yuhui Jiang Jie Ji Jie Zhang Liwei Wu Jiao Feng Yuanyuan Zheng Yan Li Ziqi Cheng Qiang Yu Jianye Wu Jingjing Li Kan Chen Chuanyong Guo Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway Mediators of Inflammation |
| title | Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway |
| title_full | Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway |
| title_fullStr | Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway |
| title_full_unstemmed | Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway |
| title_short | Cordycepin Protects against Hepatic Ischemia/Reperfusion Injury via Inhibiting MAPK/NF-κB Pathway |
| title_sort | cordycepin protects against hepatic ischemia reperfusion injury via inhibiting mapk nf κb pathway |
| url | http://dx.doi.org/10.1155/2022/5676256 |
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