Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation
Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/176535 |
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| author | Yuyun Yueniwati Valentina Yurina Mohammad Rasjad Indra |
| author_facet | Yuyun Yueniwati Valentina Yurina Mohammad Rasjad Indra |
| author_sort | Yuyun Yueniwati |
| collection | DOAJ |
| description | Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children. Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT was examined by utilizing high resolution B-mode ultrasound. Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case children. CIMT of case children was significantly different from that of controlled children (0.61±0.012 mm versus, 0.52±0.015 mm, P= 0.021). Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples. |
| format | Article |
| id | doaj-art-cf0a6ee1758a4903b9b994188f611a2f |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-cf0a6ee1758a4903b9b994188f611a2f2025-02-03T06:01:35ZengWileyNeurology Research International2090-18522090-18602014-01-01201410.1155/2014/176535176535Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G MutationYuyun Yueniwati0Valentina Yurina1Mohammad Rasjad Indra2Radiology Department, Medical Faculty, University of Brawijaya, Malang 65145, IndonesiaPharmacy Study Program, Medical Faculty, University of Brawijaya, Malang 65145, IndonesiaPhysiology Laboratory, Medical Faculty, University of Brawijaya, Malang 65145, IndonesiaCarotid intima media thickness (CIMT) is clearly associated with atherosclerosis. Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism. This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children. Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled). The CIMT was examined by utilizing high resolution B-mode ultrasound. Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method. Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively. A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children. G-2464A polymorphism was found in 5% of case children. CIMT of case children was significantly different from that of controlled children (0.61±0.012 mm versus, 0.52±0.015 mm, P= 0.021). Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter. OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples.http://dx.doi.org/10.1155/2014/176535 |
| spellingShingle | Yuyun Yueniwati Valentina Yurina Mohammad Rasjad Indra Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation Neurology Research International |
| title | Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation |
| title_full | Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation |
| title_fullStr | Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation |
| title_full_unstemmed | Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation |
| title_short | Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation |
| title_sort | thicker carotid intima media thickness in children with monocyte chemoattractant protein 1 a 2138t and a 2464g mutation |
| url | http://dx.doi.org/10.1155/2014/176535 |
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