Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering
Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/3206807 |
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| author | Umesh D. Wankhade Michael Shen Ravindra Kolhe Sadanand Fulzele |
| author_facet | Umesh D. Wankhade Michael Shen Ravindra Kolhe Sadanand Fulzele |
| author_sort | Umesh D. Wankhade |
| collection | DOAJ |
| description | Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source of several adipokines and cytokines which have been deemed important for both normal metabolic function and disease formation. The discoveries of metabolically active brown AT in adult humans and adipose tissue derived stem cells (ADSC) have been key findings in the past decade with potential therapeutic implications. ADSCs represent an enticing pool of multipotent adult stem cells because of their noncontroversial nature, relative abundance, ease of isolation, and expandability. A decade and a half since the discovery of ADSCs, the scientific community is still working to uncover their therapeutic potential in a wide range of diseases. In this review, we provide an overview of the recent developments in the field of ADSCs and examine their potential use in transplantation and cell-based therapies for the regeneration of diseased organs and systems. We also hope to provide perspective on how to best utilize this readily available, powerful pool of stem cells in the future. |
| format | Article |
| id | doaj-art-cf02b44d5f0343b093f8d44b5cc8ef05 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-cf02b44d5f0343b093f8d44b5cc8ef052025-08-20T02:19:30ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/32068073206807Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue EngineeringUmesh D. Wankhade0Michael Shen1Ravindra Kolhe2Sadanand Fulzele3National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD 20814, USADuke University, Durham, NC 27710, USADepartment of Pathology, Georgia Regents University, Augusta, GA 30912, USADepartment of Orthopedics, Georgia Regents University, Augusta, GA 30912, USAObesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source of several adipokines and cytokines which have been deemed important for both normal metabolic function and disease formation. The discoveries of metabolically active brown AT in adult humans and adipose tissue derived stem cells (ADSC) have been key findings in the past decade with potential therapeutic implications. ADSCs represent an enticing pool of multipotent adult stem cells because of their noncontroversial nature, relative abundance, ease of isolation, and expandability. A decade and a half since the discovery of ADSCs, the scientific community is still working to uncover their therapeutic potential in a wide range of diseases. In this review, we provide an overview of the recent developments in the field of ADSCs and examine their potential use in transplantation and cell-based therapies for the regeneration of diseased organs and systems. We also hope to provide perspective on how to best utilize this readily available, powerful pool of stem cells in the future.http://dx.doi.org/10.1155/2016/3206807 |
| spellingShingle | Umesh D. Wankhade Michael Shen Ravindra Kolhe Sadanand Fulzele Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering Stem Cells International |
| title | Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering |
| title_full | Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering |
| title_fullStr | Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering |
| title_full_unstemmed | Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering |
| title_short | Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering |
| title_sort | advances in adipose derived stem cells isolation characterization and application in regenerative tissue engineering |
| url | http://dx.doi.org/10.1155/2016/3206807 |
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