Evaluating the efficacy and safety of immune checkpoint inhibitors in first and second-line treatments for recurrent and metastatic head and neck squamous cell carcinoma: a systematic review and network meta-analysis of RCTs with a focus on PD-L1 expression

Evaluating the efficacy and safety of immune checkpoint inhibitors in first and second-line treatments for recurrent and metastatic head and neck squamous cell carcinoma: a systematic review and network meta-analysis of RCTs with a focus on PD-L1 expression

IntroductionThis study systematically reviewed and conducted a network meta-analysis to assess the efficacy and safety of first-line and second-line immunotherapy treatments for recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). The findings aim to provide robust evidence to...

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Main Authors: Wei Chen, Qiance Wei, Tong Xiao, Jinghan Lai, Mengmeng Huang, Yueran Ma, Lili Zhang, Wenxin Xue, Shui Liu, Lichaoyue Sun, Wenshu Li, Zhijun Bu, Junge Lou, Zhaolan Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
R/M HNSCC
ICIs
efficacy
safety
network meta-analysis
PD-L1 expression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1508885/full
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