SAHA inhibits lung fibroblast activation by increasing p66Shc expression epigenetically

SAHA inhibits lung fibroblast activation by increasing p66Shc expression epigenetically

Abstract Objectives To investigate the effects of suberoylanilide hydroxamic acid (SAHA) on lung fibroblast activation and to examine the role of p66Shc in this process. Methods An in vitro pulmonary fibrosis model was established using transforming growth factor‐β (TGF‐β)‐induced MRC‐5 lung fibrobl...

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Bibliographic Details
Main Authors: Yiheng Dong, Jieting Peng, Xiangyu Zhang, Qiong Wang, Xing Lyu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Aging Medicine
Subjects:
histone modification
lung fibroblasts
p66Shc
pulmonary fibrosis
SAHA
Online Access:https://doi.org/10.1002/agm2.12385
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