Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section
Introduction: Hypotension after spinal anaesthesia for an LSCS is frequent even with sufficient fluid replacement. Phenylephrine is suggested for managing hypotension in caesarean sections. Our study aimed to analyse the efficacy of bolus norepinephrine doses in comparison with phenylephrine in trea...
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KIMS Foundation and Research Center
2025-03-01
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| author | Divakar SR Shivakumar G Kiran AV Kavya D |
| author_facet | Divakar SR Shivakumar G Kiran AV Kavya D |
| author_sort | Divakar SR |
| collection | DOAJ |
| description | Introduction: Hypotension after spinal anaesthesia for an LSCS is frequent even with sufficient fluid replacement. Phenylephrine is suggested for managing hypotension in caesarean sections. Our study aimed to analyse the efficacy of bolus norepinephrine doses in comparison with phenylephrine in treating spinal hypotension during elective caesarean section.
Methods: This randomized double-blind study was performed at Mandya Institute of Medical Sciences, Mandya. 160 patients of age group 20–30 years posted for elective caesarean section were divided into two equal groups (A and B) using computer generated number system. Group A received injection phenylephrine 50mcg bolus dose while Group B received injection noradrenaline 4mcg for treating hypotension. The aim was to assess the quantity of bolus doses of phenylephrine and noradrenaline needed to address spinal hypotension. The examination of the frequency of negative effects on maternal and foetal parameters was the secondary aim.
Results: The hypotension in Group A was treated with lower dose of vasopressor compared to Group B (52.50±10.966 vs 8.15 ± 1.571) and the difference was found to be statistically significant with p value 0.002. Incidence of bradycardia seen in Group A was comparable with Group B, but statistically not significant. Maternal complications and fetal parameters were comparable between two groups.
Conclusion: Intermittent boluses of phenylephrine are effective in the management of spinal hypotension during elective caesarean section. The maternal complications and fetal parameters were comparable in both the groups. Phenylephrine boluses can be considered in treating post spinal hypotension during elective caesarean sections. |
| format | Article |
| id | doaj-art-ced6e63cdcfd4e76b6f2b5461aa2f673 |
| institution | OA Journals |
| issn | 2321-1326 2394-112X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KIMS Foundation and Research Center |
| record_format | Article |
| series | Journal of Medical and Scientific Research |
| spelling | doaj-art-ced6e63cdcfd4e76b6f2b5461aa2f6732025-08-20T02:16:14ZengKIMS Foundation and Research CenterJournal of Medical and Scientific Research2321-13262394-112X2025-03-01131273110.17727/JMSR.2024/13-5Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean sectionDivakar SR0Shivakumar G1Kiran AV2Kavya D3Department of Anaesthesia, Mandya Institute of Medical Sciences, Mandya, Karnataka 571401, India Department of Anaesthesia, Mandya Institute of Medical Sciences, Mandya, Karnataka 571401, India Department of Anaesthesia, Mandya Institute of Medical Sciences, Mandya, Karnataka 571401, India Department of Anaesthesia, Mandya Institute of Medical Sciences, Mandya, Karnataka 571401, India Introduction: Hypotension after spinal anaesthesia for an LSCS is frequent even with sufficient fluid replacement. Phenylephrine is suggested for managing hypotension in caesarean sections. Our study aimed to analyse the efficacy of bolus norepinephrine doses in comparison with phenylephrine in treating spinal hypotension during elective caesarean section. Methods: This randomized double-blind study was performed at Mandya Institute of Medical Sciences, Mandya. 160 patients of age group 20–30 years posted for elective caesarean section were divided into two equal groups (A and B) using computer generated number system. Group A received injection phenylephrine 50mcg bolus dose while Group B received injection noradrenaline 4mcg for treating hypotension. The aim was to assess the quantity of bolus doses of phenylephrine and noradrenaline needed to address spinal hypotension. The examination of the frequency of negative effects on maternal and foetal parameters was the secondary aim. Results: The hypotension in Group A was treated with lower dose of vasopressor compared to Group B (52.50±10.966 vs 8.15 ± 1.571) and the difference was found to be statistically significant with p value 0.002. Incidence of bradycardia seen in Group A was comparable with Group B, but statistically not significant. Maternal complications and fetal parameters were comparable between two groups. Conclusion: Intermittent boluses of phenylephrine are effective in the management of spinal hypotension during elective caesarean section. The maternal complications and fetal parameters were comparable in both the groups. Phenylephrine boluses can be considered in treating post spinal hypotension during elective caesarean sections. https://jmsronline.com/archive-article/intravenous-bolus-phenylephrine-noradrenaline-treatment-hypotensioncaesarean sectionhypotensionnorepinephrinephenylephrinevasopressors |
| spellingShingle | Divakar SR Shivakumar G Kiran AV Kavya D Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section Journal of Medical and Scientific Research caesarean section hypotension norepinephrine phenylephrine vasopressors |
| title | Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| title_full | Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| title_fullStr | Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| title_full_unstemmed | Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| title_short | Comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| title_sort | comparative evaluation of intravenous bolus of phenylephrine versus intravenous bolus of noradrenaline for treatment of hypotension in patients undergoing elective caesarean section |
| topic | caesarean section hypotension norepinephrine phenylephrine vasopressors |
| url | https://jmsronline.com/archive-article/intravenous-bolus-phenylephrine-noradrenaline-treatment-hypotension |
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