Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes

Injectable ECM-mimetic dynamic hydrogels abolish ferroptosis-induced post-discectomy herniation through delivering nucleus pulposus progenitor cell-derived exosomes

Abstract Discectomy-induced ferroptosis of nucleus pulposus cells (NPCs) contributes to postoperative lumbar disc herniation (LDH) recurrence and intervertebral disc degeneration (IDD). We discover that nucleus pulposus progenitor cells (NPPCs) could imprint ferroptosis resistance into NPCs through...

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Bibliographic Details
Main Authors:	Wenkai Wang, Zhuo Cheng, Miao Yu, Ke Liu, Hongli Duan, Yang Zhang, Xinle Huang, Menghuan Li, Changqing Li, Yan Hu, Zhong Luo, Minghan Liu
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-025-58447-5
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