Apathy in Parkinson’s Disease: An Electrophysiological Study
In Parkinson’s disease (PD), apathy (or loss of motivation) is frequent. Nevertheless, the contribution of attentional disorders to its genesis is still not clearly known. We want to determine the relation existing between apathy and attentional disorders by using P300a (or novelty P3) as a marker o...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/290513 |
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| author | Stéphane Mathis Jean-Philippe Neau Claudette Pluchon Marie-Noëlle Fargeau Stéphane Karolewicz Anna Iljicsov Roger Gil |
| author_facet | Stéphane Mathis Jean-Philippe Neau Claudette Pluchon Marie-Noëlle Fargeau Stéphane Karolewicz Anna Iljicsov Roger Gil |
| author_sort | Stéphane Mathis |
| collection | DOAJ |
| description | In Parkinson’s disease (PD), apathy (or loss of motivation) is frequent. Nevertheless, the contribution of attentional disorders to its genesis is still not clearly known. We want to determine the relation existing between apathy and attentional disorders by using P300a (or novelty P3) as a marker of the attentional process. The study included 25 patients (13 women and 12 men) with PD for whom we have determined the relationship between automatic attention (represented by P300a) and motor status, apathy, executive dysfunction, mental flexibility, inhibitory control, and depression/anxiety. We have found a correlation between the apathy score and amplitude of novelty P300 during the ON period and also a correlation of the apathy score with a decrease in amplitude of P300 during the OFF period. In a linear regression model, changes in the P300a predicted the severity of apathy independently of any other variable. We concluded firstly that the reduction in amplitude of the P300a wave was a neurophysiological marker of apathy in PD and secondly that apathy led to both dopaminergic denervation (mesolimbic) and nondopaminergic (dorsolateral prefrontal-subcortical) dysfunction. |
| format | Article |
| id | doaj-art-cec6c78bcaa34216bbb183d5d8021325 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-cec6c78bcaa34216bbb183d5d80213252025-02-03T01:26:11ZengWileyNeurology Research International2090-18522090-18602014-01-01201410.1155/2014/290513290513Apathy in Parkinson’s Disease: An Electrophysiological StudyStéphane Mathis0Jean-Philippe Neau1Claudette Pluchon2Marie-Noëlle Fargeau3Stéphane Karolewicz4Anna Iljicsov5Roger Gil6Department of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceDepartment of Neurology, CHU Poitiers, University of Poitiers, 2 rue de la Milétrie, 86021 Poitiers, FranceIn Parkinson’s disease (PD), apathy (or loss of motivation) is frequent. Nevertheless, the contribution of attentional disorders to its genesis is still not clearly known. We want to determine the relation existing between apathy and attentional disorders by using P300a (or novelty P3) as a marker of the attentional process. The study included 25 patients (13 women and 12 men) with PD for whom we have determined the relationship between automatic attention (represented by P300a) and motor status, apathy, executive dysfunction, mental flexibility, inhibitory control, and depression/anxiety. We have found a correlation between the apathy score and amplitude of novelty P300 during the ON period and also a correlation of the apathy score with a decrease in amplitude of P300 during the OFF period. In a linear regression model, changes in the P300a predicted the severity of apathy independently of any other variable. We concluded firstly that the reduction in amplitude of the P300a wave was a neurophysiological marker of apathy in PD and secondly that apathy led to both dopaminergic denervation (mesolimbic) and nondopaminergic (dorsolateral prefrontal-subcortical) dysfunction.http://dx.doi.org/10.1155/2014/290513 |
| spellingShingle | Stéphane Mathis Jean-Philippe Neau Claudette Pluchon Marie-Noëlle Fargeau Stéphane Karolewicz Anna Iljicsov Roger Gil Apathy in Parkinson’s Disease: An Electrophysiological Study Neurology Research International |
| title | Apathy in Parkinson’s Disease: An Electrophysiological Study |
| title_full | Apathy in Parkinson’s Disease: An Electrophysiological Study |
| title_fullStr | Apathy in Parkinson’s Disease: An Electrophysiological Study |
| title_full_unstemmed | Apathy in Parkinson’s Disease: An Electrophysiological Study |
| title_short | Apathy in Parkinson’s Disease: An Electrophysiological Study |
| title_sort | apathy in parkinson s disease an electrophysiological study |
| url | http://dx.doi.org/10.1155/2014/290513 |
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