Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos
ABSTRACT Objective: Omega-6 and omega-3 long-chain polyunsaturated fatty acids (PUFAs) play opposing roles in inflammation, anxiety, and nociception, all of which are closely associated with chronic pain. We hypothesized that diets high in omega-6 arachidonic acid (C20:4n-6, AA) and low in combine...
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Cambridge University Press
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| Series: | Public Health Nutrition |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1368980025000102/type/journal_article |
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| author | Anne E. Sanders Jianwen Cai Martha L. Daviglus Olga Garcia-Bedoya Gary D. Slade |
| author_facet | Anne E. Sanders Jianwen Cai Martha L. Daviglus Olga Garcia-Bedoya Gary D. Slade |
| author_sort | Anne E. Sanders |
| collection | DOAJ |
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ABSTRACT
Objective:
Omega-6 and omega-3 long-chain polyunsaturated fatty acids (PUFAs) play opposing roles in inflammation, anxiety, and nociception, all of which are closely associated with chronic pain. We hypothesized that diets high in omega-6 arachidonic acid (C20:4n-6, AA) and low in combined omega-3 eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD).
Design:
We analyzed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-hr dietary recall surveys quantified intake of long-chain omega-6 and omega-3 PUFAs along with their precursors, linoleic acid (C18:2n-6, LA) and alpha linolenic acid (C18:3n-3, ALA) respectively. Omega-3 PUFAs supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted odds ratios (OR) and 95% confidence limits (CL) for associations between PUFAs and TMD.
Setting:
From 2008—2011, HCHS/SOL recruited 16,415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centers located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY.
Participants:
13,870 participants with non-missing data.
Results:
In analysis adjusted for covariates, each standard deviation increase in dietary intake of C20:4n-6, AA was associated with 12% higher odds of TMD (OR=1.12, CL:1.01, 1.24). Although the dietary intake of combined long-chain C20:5n-3, EPA and C22:6n-3 DHA was not associated with TMD, each standard deviation increase in omega-3 dietary supplement was associated with lower odds of TMD.
Conclusions:
A diet rich in C20:4n-6, AA was associated with higher odds of painful TMD.
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| format | Article |
| id | doaj-art-cec5f4b805c64f0a9da2f908f4a88082 |
| institution | Kabale University |
| issn | 1368-9800 1475-2727 |
| language | English |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Public Health Nutrition |
| spelling | doaj-art-cec5f4b805c64f0a9da2f908f4a880822025-02-03T03:27:42ZengCambridge University PressPublic Health Nutrition1368-98001475-272712910.1017/S1368980025000102Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of LatinosAnne E. Sanders0https://orcid.org/0000-0003-2607-9514Jianwen Cai1Martha L. Daviglus2Olga Garcia-Bedoya3Gary D. Slade4Department of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.Coordinating Center - Collaborative Studies Coordinating Center - UNC at Chapel Hill University of North Carolina at Chapel Hill, Chapel Hill, NC USA.Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.Department of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA.Department of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ABSTRACT Objective: Omega-6 and omega-3 long-chain polyunsaturated fatty acids (PUFAs) play opposing roles in inflammation, anxiety, and nociception, all of which are closely associated with chronic pain. We hypothesized that diets high in omega-6 arachidonic acid (C20:4n-6, AA) and low in combined omega-3 eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD). Design: We analyzed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-hr dietary recall surveys quantified intake of long-chain omega-6 and omega-3 PUFAs along with their precursors, linoleic acid (C18:2n-6, LA) and alpha linolenic acid (C18:3n-3, ALA) respectively. Omega-3 PUFAs supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted odds ratios (OR) and 95% confidence limits (CL) for associations between PUFAs and TMD. Setting: From 2008—2011, HCHS/SOL recruited 16,415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centers located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY. Participants: 13,870 participants with non-missing data. Results: In analysis adjusted for covariates, each standard deviation increase in dietary intake of C20:4n-6, AA was associated with 12% higher odds of TMD (OR=1.12, CL:1.01, 1.24). Although the dietary intake of combined long-chain C20:5n-3, EPA and C22:6n-3 DHA was not associated with TMD, each standard deviation increase in omega-3 dietary supplement was associated with lower odds of TMD. Conclusions: A diet rich in C20:4n-6, AA was associated with higher odds of painful TMD. https://www.cambridge.org/core/product/identifier/S1368980025000102/type/journal_articleOrofacial painTemporomandibular disorderHispanics/LatinosPolyunsaturated fatty acidsdietary intakefish oil supplements |
| spellingShingle | Anne E. Sanders Jianwen Cai Martha L. Daviglus Olga Garcia-Bedoya Gary D. Slade Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos Public Health Nutrition Orofacial pain Temporomandibular disorder Hispanics/Latinos Polyunsaturated fatty acids dietary intake fish oil supplements |
| title | Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos |
| title_full | Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos |
| title_fullStr | Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos |
| title_full_unstemmed | Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos |
| title_short | Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos |
| title_sort | long chain polyunsaturated fatty acids and painful temporomandibular disorder in the hispanic community health study study of latinos |
| topic | Orofacial pain Temporomandibular disorder Hispanics/Latinos Polyunsaturated fatty acids dietary intake fish oil supplements |
| url | https://www.cambridge.org/core/product/identifier/S1368980025000102/type/journal_article |
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