PKIB facilitates bladder cancer proliferation and metastasis through mediation of HSP27 phosphorylation by PKA

PKIB facilitates bladder cancer proliferation and metastasis through mediation of HSP27 phosphorylation by PKA

Abstract Cyclic AMP-dependent protein kinase A (PKA) is recognized for its pivotal involvement in various cancer types, with Protein Kinase Inhibitor Beta (PKIB) serving as an endogenous inhibitor that curtails PKA activity. Despite the documented escalation of PKIB expression in several malignancie...

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Main Authors: Xiaolong Liu, Xiaoyu Yin, Feng Yuan, Shiqing Li, Fei Xiao, Feng Zhou, Xudong Pan, Yatfaat Ho, Shuo Dong, Duan Xu, Yunqing Ma, Zhengding Cao, Zhe Lei, Yi Sun
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07814-7
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