Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry
Objective. Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes. The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization. We investigated the efficacy and safety of polymer-free ultrathin str...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/8053168 |
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| author | Ahmad Syadi Mahmood Zuhdi Florian Krackhardt Matthias W. Waliszewski Muhammad Dzafir Ismail Michael Boxberger Wan Azman Wan Ahmad |
| author_facet | Ahmad Syadi Mahmood Zuhdi Florian Krackhardt Matthias W. Waliszewski Muhammad Dzafir Ismail Michael Boxberger Wan Azman Wan Ahmad |
| author_sort | Ahmad Syadi Mahmood Zuhdi |
| collection | DOAJ |
| description | Objective. Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes. The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization. We investigated the efficacy and safety of polymer-free ultrathin strut sirolimus-probucol coated drug-eluting stents (PF-SES) for CTO lesions. Methods. Patients with CTO lesions treated with PF-SES were identified from the prospective multicenter international ISAR 2000 registry. The primary endpoint was clinically driven target lesion revascularization (TLR) at 9 months. Secondary endpoints were 9-month major adverse cardiac events (death, myocardial infarction, or TLR) (MACE) and the occurrence of stent thrombosis. Results. A total of 111 patients with CTO lesions (n=127) were available for analysis. The 9-month clinical follow-up rate was 91%. The mean reference vessel diameter and lesion length were 2.76 mm ± 0.40 and 26.8 mm ± 13.1, respectively. The overall DAPT duration was 9.7 ± 2.8 months. Only one (1%) in-hospital MI was reported. The TLR and MACE rates at 9 months were 2% (2/101) and 5.9% (6/101), respectively. The 9-month accumulated rates of definite or probable stent thrombosis was 0% (0/101). Conclusion. Revascularizations for CTO with PF-SES are associated with low rates of TLR and MACE at 9 months with no stent thrombosis. These initial findings need to be compared with results of other new generation DES of larger studies. |
| format | Article |
| id | doaj-art-ceb39cb8b41c4ee7bf6b3cc6dc82369d |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-ceb39cb8b41c4ee7bf6b3cc6dc82369d2025-02-03T06:01:23ZengWileyCardiology Research and Practice2090-80162090-05972018-01-01201810.1155/2018/80531688053168Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide RegistryAhmad Syadi Mahmood Zuhdi0Florian Krackhardt1Matthias W. Waliszewski2Muhammad Dzafir Ismail3Michael Boxberger4Wan Azman Wan Ahmad5Cardiology Unit, University Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaDepartment of Cardiology and Internal Medicine, Charité–Universitäts Medizin Berlin, Campus Virchow, Berlin, GermanyDepartment of Cardiology and Internal Medicine, Charité–Universitäts Medizin Berlin, Campus Virchow, Berlin, GermanyCardiology Unit, University Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaMedical Scientific Affairs, B. Braun Melsungen AG, Berlin, GermanyCardiology Unit, University Malaya Medical Centre, 59100 Kuala Lumpur, MalaysiaObjective. Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes. The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization. We investigated the efficacy and safety of polymer-free ultrathin strut sirolimus-probucol coated drug-eluting stents (PF-SES) for CTO lesions. Methods. Patients with CTO lesions treated with PF-SES were identified from the prospective multicenter international ISAR 2000 registry. The primary endpoint was clinically driven target lesion revascularization (TLR) at 9 months. Secondary endpoints were 9-month major adverse cardiac events (death, myocardial infarction, or TLR) (MACE) and the occurrence of stent thrombosis. Results. A total of 111 patients with CTO lesions (n=127) were available for analysis. The 9-month clinical follow-up rate was 91%. The mean reference vessel diameter and lesion length were 2.76 mm ± 0.40 and 26.8 mm ± 13.1, respectively. The overall DAPT duration was 9.7 ± 2.8 months. Only one (1%) in-hospital MI was reported. The TLR and MACE rates at 9 months were 2% (2/101) and 5.9% (6/101), respectively. The 9-month accumulated rates of definite or probable stent thrombosis was 0% (0/101). Conclusion. Revascularizations for CTO with PF-SES are associated with low rates of TLR and MACE at 9 months with no stent thrombosis. These initial findings need to be compared with results of other new generation DES of larger studies.http://dx.doi.org/10.1155/2018/8053168 |
| spellingShingle | Ahmad Syadi Mahmood Zuhdi Florian Krackhardt Matthias W. Waliszewski Muhammad Dzafir Ismail Michael Boxberger Wan Azman Wan Ahmad Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry Cardiology Research and Practice |
| title | Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry |
| title_full | Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry |
| title_fullStr | Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry |
| title_full_unstemmed | Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry |
| title_short | Efficacy and Safety of Polymer-Free Ultrathin Strut Sirolimus-Probucol Coated Drug-Eluting Stents for Chronic Total Occlusions: Insights from the Coroflex ISAR 2000 Worldwide Registry |
| title_sort | efficacy and safety of polymer free ultrathin strut sirolimus probucol coated drug eluting stents for chronic total occlusions insights from the coroflex isar 2000 worldwide registry |
| url | http://dx.doi.org/10.1155/2018/8053168 |
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