Elevated Troponin Serum Levels in Adult Onset Still’s Disease
Adult onset Still’s disease (AOSD) is a rare inflammatory systemic disease that occasionally may affect myocardium. Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory disorders. In the case of abrupt, recent onset AOSD...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2015/732095 |
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| author | Carlo Umberto Manzini Lucio Brugioni Michele Colaci Maurizio Tognetti Amelia Spinella Marco Sebastiani Dilia Giuggioli Clodoveo Ferri |
| author_facet | Carlo Umberto Manzini Lucio Brugioni Michele Colaci Maurizio Tognetti Amelia Spinella Marco Sebastiani Dilia Giuggioli Clodoveo Ferri |
| author_sort | Carlo Umberto Manzini |
| collection | DOAJ |
| description | Adult onset Still’s disease (AOSD) is a rare inflammatory systemic disease that occasionally may affect myocardium. Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory disorders. In the case of abrupt, recent onset AOSD, it could be particularly difficult to make the differential diagnosis and in particular to early detect the possible heart involvement. This latter event is suggested by the clinical history of the four patients described here, incidentally observed at our emergency room. All cases were referred because of acute illness (high fever, malaise, polyarthralgias, skin rash, and sore throat), successively classified as AOSD, and they presented abnormally high levels of serum troponin without overt symptoms of cardiac involvement. The timely treatment with steroids (3 cases) or ibuprofen (1 case) leads to the remission of clinicoserological manifestations within few weeks.
These observations suggest that early myocardial injury might be underestimated or entirely overlooked in patients with AOSD; routine cardiac assessment including troponin evaluation should be mandatory in all patients with suspected AOSD. |
| format | Article |
| id | doaj-art-ceac215fd48047f488ca331d287e332b |
| institution | Kabale University |
| issn | 2090-6889 2090-6897 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-ceac215fd48047f488ca331d287e332b2025-02-03T06:12:38ZengWileyCase Reports in Rheumatology2090-68892090-68972015-01-01201510.1155/2015/732095732095Elevated Troponin Serum Levels in Adult Onset Still’s DiseaseCarlo Umberto Manzini0Lucio Brugioni1Michele Colaci2Maurizio Tognetti3Amelia Spinella4Marco Sebastiani5Dilia Giuggioli6Clodoveo Ferri7Chair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyCritical Care Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyCritical Care Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyAdult onset Still’s disease (AOSD) is a rare inflammatory systemic disease that occasionally may affect myocardium. Diagnosis is based on typical AOSD symptoms after the exclusion of well-known infectious, neoplastic, or autoimmune/autoinflammatory disorders. In the case of abrupt, recent onset AOSD, it could be particularly difficult to make the differential diagnosis and in particular to early detect the possible heart involvement. This latter event is suggested by the clinical history of the four patients described here, incidentally observed at our emergency room. All cases were referred because of acute illness (high fever, malaise, polyarthralgias, skin rash, and sore throat), successively classified as AOSD, and they presented abnormally high levels of serum troponin without overt symptoms of cardiac involvement. The timely treatment with steroids (3 cases) or ibuprofen (1 case) leads to the remission of clinicoserological manifestations within few weeks. These observations suggest that early myocardial injury might be underestimated or entirely overlooked in patients with AOSD; routine cardiac assessment including troponin evaluation should be mandatory in all patients with suspected AOSD.http://dx.doi.org/10.1155/2015/732095 |
| spellingShingle | Carlo Umberto Manzini Lucio Brugioni Michele Colaci Maurizio Tognetti Amelia Spinella Marco Sebastiani Dilia Giuggioli Clodoveo Ferri Elevated Troponin Serum Levels in Adult Onset Still’s Disease Case Reports in Rheumatology |
| title | Elevated Troponin Serum Levels in Adult Onset Still’s Disease |
| title_full | Elevated Troponin Serum Levels in Adult Onset Still’s Disease |
| title_fullStr | Elevated Troponin Serum Levels in Adult Onset Still’s Disease |
| title_full_unstemmed | Elevated Troponin Serum Levels in Adult Onset Still’s Disease |
| title_short | Elevated Troponin Serum Levels in Adult Onset Still’s Disease |
| title_sort | elevated troponin serum levels in adult onset still s disease |
| url | http://dx.doi.org/10.1155/2015/732095 |
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