Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia
Background: Evidence is limited regarding the role of air pollution in acute lower respiratory infections among adults. We assessed the influence of long-term air pollution exposure on hospital admission for lower respiratory infections and whether there are vulnerable subgroups. Methods: We used a...
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Elsevier
2025-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024008171 |
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| author | Anna Alari Otavio Ranzani Carles Milà Sergio Olmos Xavier Basagaña Payam Dadvand Talita Duarte-Salles Mark Nieuwenhuijsen Cathryn Tonne |
| author_facet | Anna Alari Otavio Ranzani Carles Milà Sergio Olmos Xavier Basagaña Payam Dadvand Talita Duarte-Salles Mark Nieuwenhuijsen Cathryn Tonne |
| author_sort | Anna Alari |
| collection | DOAJ |
| description | Background: Evidence is limited regarding the role of air pollution in acute lower respiratory infections among adults. We assessed the influence of long-term air pollution exposure on hospital admission for lower respiratory infections and whether there are vulnerable subgroups. Methods: We used a populational cohort in Catalonia, Spain, comprising 3,817,820 adults residing in Catalonia as of January 1, 2015. Air pollution exposure was assigned to individuaĺs residential address using locally-developed models. We characterized the concentration–response functions between long-term air pollution exposure and hospital admission for lower respiratory infections between 2015 and 2019. We assessed interaction between exposure and clinical and socio-economic factors on multiplicative and additive scales. Results: An interquartile range exposure increase was associated with an 8 % (95 % Confidence Interval: 5 %–11 %) for Nitrogen Dioxide, 10 % (95 % Confidence Interval: 8 %–13 %) for Particulate Matter with diameter equal to or smaller than 2.5 µm, 5 % (95 % Confidence Interval: 3 %–7%) for Particulate Matter with diameter equal to or smaller than 10 µm and 18 % (95 % Confidence Interval: 14 %–22%) for ozone (adjusted by Nitrogen Dioxide) increase in hospital admissions for respiratory infections. Concentration-response functions were non-linear, with steeper slopes at exposures below the median or at most extreme high values. Associations were consistently greater for individuals over 65 years or with hypertension diagnosis and males. Conclusions: Long-term exposure to air pollution was positively associated with hospital admission for lower respiratory infections. Individuals who were older than 65 years, hypertensive or male were most vulnerable. |
| format | Article |
| id | doaj-art-ceab942912344ca0b5dfc728b4bd9a35 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj-art-ceab942912344ca0b5dfc728b4bd9a352025-01-24T04:44:08ZengElsevierEnvironment International0160-41202025-01-01195109230Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in CataloniaAnna Alari0Otavio Ranzani1Carles Milà2Sergio Olmos3Xavier Basagaña4Payam Dadvand5Talita Duarte-Salles6Mark Nieuwenhuijsen7Cathryn Tonne8Barcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainFundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the NetherlandsBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, SpainBarcelona Institute for Global Health, ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Corresponding author at: Carrer del Dr. Aiguader 88, 08003 Barcelona, Spain.Background: Evidence is limited regarding the role of air pollution in acute lower respiratory infections among adults. We assessed the influence of long-term air pollution exposure on hospital admission for lower respiratory infections and whether there are vulnerable subgroups. Methods: We used a populational cohort in Catalonia, Spain, comprising 3,817,820 adults residing in Catalonia as of January 1, 2015. Air pollution exposure was assigned to individuaĺs residential address using locally-developed models. We characterized the concentration–response functions between long-term air pollution exposure and hospital admission for lower respiratory infections between 2015 and 2019. We assessed interaction between exposure and clinical and socio-economic factors on multiplicative and additive scales. Results: An interquartile range exposure increase was associated with an 8 % (95 % Confidence Interval: 5 %–11 %) for Nitrogen Dioxide, 10 % (95 % Confidence Interval: 8 %–13 %) for Particulate Matter with diameter equal to or smaller than 2.5 µm, 5 % (95 % Confidence Interval: 3 %–7%) for Particulate Matter with diameter equal to or smaller than 10 µm and 18 % (95 % Confidence Interval: 14 %–22%) for ozone (adjusted by Nitrogen Dioxide) increase in hospital admissions for respiratory infections. Concentration-response functions were non-linear, with steeper slopes at exposures below the median or at most extreme high values. Associations were consistently greater for individuals over 65 years or with hypertension diagnosis and males. Conclusions: Long-term exposure to air pollution was positively associated with hospital admission for lower respiratory infections. Individuals who were older than 65 years, hypertensive or male were most vulnerable.http://www.sciencedirect.com/science/article/pii/S0160412024008171Lower respiratory infectionsAir pollutionLong-term exposureAdultsTime-to-event analysis |
| spellingShingle | Anna Alari Otavio Ranzani Carles Milà Sergio Olmos Xavier Basagaña Payam Dadvand Talita Duarte-Salles Mark Nieuwenhuijsen Cathryn Tonne Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia Environment International Lower respiratory infections Air pollution Long-term exposure Adults Time-to-event analysis |
| title | Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia |
| title_full | Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia |
| title_fullStr | Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia |
| title_full_unstemmed | Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia |
| title_short | Long-term exposure to air pollution and lower respiratory infections in a large population-based adult cohort in Catalonia |
| title_sort | long term exposure to air pollution and lower respiratory infections in a large population based adult cohort in catalonia |
| topic | Lower respiratory infections Air pollution Long-term exposure Adults Time-to-event analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024008171 |
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