Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes
Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities. The free-radical-scavenging ability of the metal complexes was determined by the...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2012/795812 |
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| author | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Abu Bakar Mohamad |
| author_facet | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Abu Bakar Mohamad |
| author_sort | Ahmed A. Al-Amiery |
| collection | DOAJ |
| description | Metal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities. The free-radical-scavenging ability of the metal complexes was determined by their interaction with the stable free radical 2,2′′-diphenyl-1-picrylhydrazyl, and all the compounds showed encouraging antioxidant activities. DFT calculations of the Cu complex were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms. |
| format | Article |
| id | doaj-art-ce9e35f14851408eab84de6541641909 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-ce9e35f14851408eab84de65416419092025-02-03T01:24:30ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2012-01-01201210.1155/2012/795812795812Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone ComplexesAhmed A. Al-Amiery0Abdul Amir H. Kadhum1Abu Bakar Mohamad2Department of Chemical and Process Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaDepartment of Chemical and Process Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaDepartment of Chemical and Process Engineering, Faculty of Engineering and Built Environment, University of Kebangsaan Malaysia, 43600 Bangi, Selangor, MalaysiaMetal complexes of (Z)-2-(pyrrolidin-2-ylidene)hydrazinecarbothioamide (L) with Cu(II), Co(II), and Ni(II) chlorides were tested against selected types of fungi and were found to have significant antifungal activities. The free-radical-scavenging ability of the metal complexes was determined by their interaction with the stable free radical 2,2′′-diphenyl-1-picrylhydrazyl, and all the compounds showed encouraging antioxidant activities. DFT calculations of the Cu complex were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.http://dx.doi.org/10.1155/2012/795812 |
| spellingShingle | Ahmed A. Al-Amiery Abdul Amir H. Kadhum Abu Bakar Mohamad Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes Bioinorganic Chemistry and Applications |
| title | Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes |
| title_full | Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes |
| title_fullStr | Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes |
| title_full_unstemmed | Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes |
| title_short | Antifungal and Antioxidant Activities of Pyrrolidone Thiosemicarbazone Complexes |
| title_sort | antifungal and antioxidant activities of pyrrolidone thiosemicarbazone complexes |
| url | http://dx.doi.org/10.1155/2012/795812 |
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