Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report
Abstract Background Cemento-osseous dysplasia (COD) is the most common apical radiopaque lesion that develops in the tooth-bearing area. However, large, destructive lesions are rare. Herein, we report a case in which COD extended to bilateral condyles, affecting the entire mandible, and was managed...
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BMC
2025-01-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-025-05514-4 |
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| author | Chieh Ling Chiang Tzu Huan Huang |
| author_facet | Chieh Ling Chiang Tzu Huan Huang |
| author_sort | Chieh Ling Chiang |
| collection | DOAJ |
| description | Abstract Background Cemento-osseous dysplasia (COD) is the most common apical radiopaque lesion that develops in the tooth-bearing area. However, large, destructive lesions are rare. Herein, we report a case in which COD extended to bilateral condyles, affecting the entire mandible, and was managed with denosumab rather than surgical resection. Case Presentation A 45-year-old woman presented to our hospital with progressive, large, destructive COD involving the entire mandible, including bilateral condyles, and associated bony expansion, which led to facial deformity and malocclusion. The patient declined total mandible resection and opted for off-label denosumab use instead. Although rapid ossification of the osteolytic lesion was observed after 9 months of treatment, the lesion volume remained unchanged. Single-photon emission computed tomography performed at follow-up revealed stable disease without progression. Conclusion Denosumab may help prevent the progression of severe, destructive COD in patients averse to surgical intervention. |
| format | Article |
| id | doaj-art-ce8e8cf614b24cfcb9a82aae1fd9f470 |
| institution | Kabale University |
| issn | 1472-6831 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj-art-ce8e8cf614b24cfcb9a82aae1fd9f4702025-02-02T12:45:17ZengBMCBMC Oral Health1472-68312025-01-012511710.1186/s12903-025-05514-4Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case reportChieh Ling Chiang0Tzu Huan Huang1Mackay Memorial Hospital, Hsinchu BranchMackay Memorial HospitalAbstract Background Cemento-osseous dysplasia (COD) is the most common apical radiopaque lesion that develops in the tooth-bearing area. However, large, destructive lesions are rare. Herein, we report a case in which COD extended to bilateral condyles, affecting the entire mandible, and was managed with denosumab rather than surgical resection. Case Presentation A 45-year-old woman presented to our hospital with progressive, large, destructive COD involving the entire mandible, including bilateral condyles, and associated bony expansion, which led to facial deformity and malocclusion. The patient declined total mandible resection and opted for off-label denosumab use instead. Although rapid ossification of the osteolytic lesion was observed after 9 months of treatment, the lesion volume remained unchanged. Single-photon emission computed tomography performed at follow-up revealed stable disease without progression. Conclusion Denosumab may help prevent the progression of severe, destructive COD in patients averse to surgical intervention.https://doi.org/10.1186/s12903-025-05514-4Cemento-osseous dysplasiaFibro-osseous lesionDenosumab |
| spellingShingle | Chieh Ling Chiang Tzu Huan Huang Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report BMC Oral Health Cemento-osseous dysplasia Fibro-osseous lesion Denosumab |
| title | Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report |
| title_full | Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report |
| title_fullStr | Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report |
| title_full_unstemmed | Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report |
| title_short | Denosumab usage in atypical cemento-osseous dysplasia involving the entire mandible: a case report |
| title_sort | denosumab usage in atypical cemento osseous dysplasia involving the entire mandible a case report |
| topic | Cemento-osseous dysplasia Fibro-osseous lesion Denosumab |
| url | https://doi.org/10.1186/s12903-025-05514-4 |
| work_keys_str_mv | AT chiehlingchiang denosumabusageinatypicalcementoosseousdysplasiainvolvingtheentiremandibleacasereport AT tzuhuanhuang denosumabusageinatypicalcementoosseousdysplasiainvolvingtheentiremandibleacasereport |