Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer
ABSTRACT In early‐stage lung cancer, lung function appears to be less compromised after segmentectomy than lobectomy, though the advantage seems modest. We aimed to re‐assess postoperative lung function in surgical patients, with a particular focus on the diffusion capacity for carbon monoxide (DLCO...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15515 |
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| author | Ernesto Crisafulli Claudio Micheletto Alessio Campisi Emanuele Vocale Chiara Schiena Giulia Sartori Gianluca Gaburro Elide Felici Maurizio Infante |
| author_facet | Ernesto Crisafulli Claudio Micheletto Alessio Campisi Emanuele Vocale Chiara Schiena Giulia Sartori Gianluca Gaburro Elide Felici Maurizio Infante |
| author_sort | Ernesto Crisafulli |
| collection | DOAJ |
| description | ABSTRACT In early‐stage lung cancer, lung function appears to be less compromised after segmentectomy than lobectomy, though the advantage seems modest. We aimed to re‐assess postoperative lung function in surgical patients, with a particular focus on the diffusion capacity for carbon monoxide (DLCO). We evaluated all patients who underwent either lobectomy or segmentectomy for T1a‐c lung cancer at our center between March 2016 and March 2023. From January to June 2024, patients who had undergone segmentectomy, along with a matched cohort of patients who had undergone lobectomy, were invited for a repeat lung function evaluation. Patients were matched 1:1 based on age, sex, surgical approach, year in which the procedure was performed, and tumor location. Lung function testing data including DLCO were then compared to preoperative measures. During the study period, 480 patients received a lobectomy, and 97 received a segmentectomy. Complete lung function evaluation for the study was available for 52 patients (26 matched pairs). The median time from lung resection to repeat spirometry was 35 months. A modest reduction of lung function measures was observed in the segmentectomy group. Conversely, all lung function measures, including DLCO, were significantly impaired in the lobectomy group. In early‐stage lung cancer, patients who perform segmentectomy demonstrated better long‐term lung function preservation compared to those who underwent lobectomy. Whenever feasible, segmentectomy should be considered the procedure of choice for early‐stage lung cancer patients. |
| format | Article |
| id | doaj-art-ce8656162d484a169ef8e83897291eee |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-ce8656162d484a169ef8e83897291eee2025-01-30T22:40:34ZengWileyThoracic Cancer1759-77061759-77142025-01-01162n/an/a10.1111/1759-7714.15515Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung CancerErnesto Crisafulli0Claudio Micheletto1Alessio Campisi2Emanuele Vocale3Chiara Schiena4Giulia Sartori5Gianluca Gaburro6Elide Felici7Maurizio Infante8Department of Medicine, Respiratory Medicine Unit University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona ItalyPulmonology Unit Verona Integrated University Hospital Verona ItalyDepartment of Thoracic Surgery University and Hospital Trust‐Ospedale Borgo Trento Verona ItalyDepartment of Thoracic Surgery University and Hospital Trust‐Ospedale Borgo Trento Verona ItalyDepartment of Thoracic Surgery University and Hospital Trust‐Ospedale Borgo Trento Verona ItalyDepartment of Medicine, Respiratory Medicine Unit University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona ItalyDepartment of Medicine, Respiratory Medicine Unit University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona ItalyDepartment of Medicine, Respiratory Medicine Unit University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona Verona ItalyDepartment of Thoracic Surgery University and Hospital Trust‐Ospedale Borgo Trento Verona ItalyABSTRACT In early‐stage lung cancer, lung function appears to be less compromised after segmentectomy than lobectomy, though the advantage seems modest. We aimed to re‐assess postoperative lung function in surgical patients, with a particular focus on the diffusion capacity for carbon monoxide (DLCO). We evaluated all patients who underwent either lobectomy or segmentectomy for T1a‐c lung cancer at our center between March 2016 and March 2023. From January to June 2024, patients who had undergone segmentectomy, along with a matched cohort of patients who had undergone lobectomy, were invited for a repeat lung function evaluation. Patients were matched 1:1 based on age, sex, surgical approach, year in which the procedure was performed, and tumor location. Lung function testing data including DLCO were then compared to preoperative measures. During the study period, 480 patients received a lobectomy, and 97 received a segmentectomy. Complete lung function evaluation for the study was available for 52 patients (26 matched pairs). The median time from lung resection to repeat spirometry was 35 months. A modest reduction of lung function measures was observed in the segmentectomy group. Conversely, all lung function measures, including DLCO, were significantly impaired in the lobectomy group. In early‐stage lung cancer, patients who perform segmentectomy demonstrated better long‐term lung function preservation compared to those who underwent lobectomy. Whenever feasible, segmentectomy should be considered the procedure of choice for early‐stage lung cancer patients.https://doi.org/10.1111/1759-7714.15515diffusion capacity for carbon monoxideearly‐stage lung cancerlong‐term evaluationlung functionsegmentectomy |
| spellingShingle | Ernesto Crisafulli Claudio Micheletto Alessio Campisi Emanuele Vocale Chiara Schiena Giulia Sartori Gianluca Gaburro Elide Felici Maurizio Infante Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer Thoracic Cancer diffusion capacity for carbon monoxide early‐stage lung cancer long‐term evaluation lung function segmentectomy |
| title | Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer |
| title_full | Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer |
| title_fullStr | Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer |
| title_full_unstemmed | Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer |
| title_short | Postoperative Lung Function Advantages in Pulmonary Segmentectomy for Early‐Stage Lung Cancer |
| title_sort | postoperative lung function advantages in pulmonary segmentectomy for early stage lung cancer |
| topic | diffusion capacity for carbon monoxide early‐stage lung cancer long‐term evaluation lung function segmentectomy |
| url | https://doi.org/10.1111/1759-7714.15515 |
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