Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers
A better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate cancer (PCa). Several groups investigated protein-glycan interactions as critical factors for crosstalk between prostate tumors and their microe...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/519436 |
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| _version_ | 1832552530098257920 |
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| author | Diego J. Laderach Lucas Gentilini Felipe M. Jaworski Daniel Compagno |
| author_facet | Diego J. Laderach Lucas Gentilini Felipe M. Jaworski Daniel Compagno |
| author_sort | Diego J. Laderach |
| collection | DOAJ |
| description | A better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate cancer (PCa). Several groups investigated protein-glycan interactions as critical factors for crosstalk between prostate tumors and their microenvironment. This review both discusses whether the “galectin-signature” might serve as a reliable biomarker for the identification of patients with high risk of metastasis and assesses the galectin-glycan lattices as potential novel targets for anticancer therapies. The ultimate goal of this review is to convey how basic findings related to galectins could be in turn translated into clinical settings for patients with advanced PCa. |
| format | Article |
| id | doaj-art-ce6c35f5207e407ca5bbaa1d831f9a97 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-ce6c35f5207e407ca5bbaa1d831f9a972025-02-03T05:58:29ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/519436519436Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate CancersDiego J. Laderach0Lucas Gentilini1Felipe M. Jaworski2Daniel Compagno3Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Buenos Aires, ArgentinaLaboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Buenos Aires, ArgentinaLaboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Buenos Aires, ArgentinaLaboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Buenos Aires, ArgentinaA better understanding of multimolecular interactions involved in tumor dissemination is required to identify new effective therapies for advanced prostate cancer (PCa). Several groups investigated protein-glycan interactions as critical factors for crosstalk between prostate tumors and their microenvironment. This review both discusses whether the “galectin-signature” might serve as a reliable biomarker for the identification of patients with high risk of metastasis and assesses the galectin-glycan lattices as potential novel targets for anticancer therapies. The ultimate goal of this review is to convey how basic findings related to galectins could be in turn translated into clinical settings for patients with advanced PCa.http://dx.doi.org/10.1155/2013/519436 |
| spellingShingle | Diego J. Laderach Lucas Gentilini Felipe M. Jaworski Daniel Compagno Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers Prostate Cancer |
| title | Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers |
| title_full | Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers |
| title_fullStr | Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers |
| title_full_unstemmed | Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers |
| title_short | Galectins as New Prognostic Markers and Potential Therapeutic Targets for Advanced Prostate Cancers |
| title_sort | galectins as new prognostic markers and potential therapeutic targets for advanced prostate cancers |
| url | http://dx.doi.org/10.1155/2013/519436 |
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