Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles
Air pollution by particulate matter (PM) has been associated with cardiopulmonary morbidity and mortality in many recent epidemiological studies. It has been shown that transition metal compounds, well- known toxic components of PM, are able to induce hypothermia following whole-body inhalation expo...
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| Format: | Article |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-12-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/433 |
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| author | D. V. Petrovskii A. V. Romashchenko S. Yu. Troitskii M. P. Moshkin |
| author_facet | D. V. Petrovskii A. V. Romashchenko S. Yu. Troitskii M. P. Moshkin |
| author_sort | D. V. Petrovskii |
| collection | DOAJ |
| description | Air pollution by particulate matter (PM) has been associated with cardiopulmonary morbidity and mortality in many recent epidemiological studies. It has been shown that transition metal compounds, well- known toxic components of PM, are able to induce hypothermia following whole-body inhalation exposure. Low temperature appears to protect tissue against toxic effects of PM metal compounds in vivo and in vitro. To study the role of soluble and insoluble irritants in the induction of the hypothermic response, we analyzed the decrease in mouse body temperature (Δtbody) after intranasal administration of PtO nanoparticles or a K2[PtCl 4] solution. Between-strain differences in Δtbody after intranasal administration of the irritants were evaluated using 6 inbred (BALB/cJ, C57BL/6J, AKR/OlaHsd, DBA/2JRccHsd, C3H/HeNHsd, and SJL/J) and 2 outbred mouse strains (SCID and CD1). BALB/cJ and SCID mice showed the most pronounced effect of intranasal administration of the xenobiotic on tbody. Thus, tbody was significantly lower after nasal administration the PtO nanoparticles than after administration of the K2[PtCl 4] solution. To study the mechanism of this decrease, we compared the respective values for Δtbody following intranasal, intravenous and peroral administration of PtO nanoparticles in Balb/c mice. Neither intravenous nor peroral administration had any effect on mouse body temperature. This fact together with data on the dynamics of the decrease in mouse body temperature following intranasal administration of PtO nanoparticles (max Δtbody ~ 80–100 min) allowed us to assume that this process is under nervous regulation. The correlation found between our data and some well-known phenotypic characteristics (phenome.jax.org) of the mouse strains used confirms this hypothesis. |
| format | Article |
| id | doaj-art-ce6a023d72bd4e878fead156e5110f45 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-ce6a023d72bd4e878fead156e5110f452025-02-01T09:58:02ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-12-0119443944410.18699/VJ15.058391Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticlesD. V. Petrovskii0A. V. Romashchenko1S. Yu. Troitskii2M. P. Moshkin3Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, Russia Design Technological Institute of Digital Technique SB RAS, Novosibirsk, RussiaBoreskov Institute of Catalysis SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaAir pollution by particulate matter (PM) has been associated with cardiopulmonary morbidity and mortality in many recent epidemiological studies. It has been shown that transition metal compounds, well- known toxic components of PM, are able to induce hypothermia following whole-body inhalation exposure. Low temperature appears to protect tissue against toxic effects of PM metal compounds in vivo and in vitro. To study the role of soluble and insoluble irritants in the induction of the hypothermic response, we analyzed the decrease in mouse body temperature (Δtbody) after intranasal administration of PtO nanoparticles or a K2[PtCl 4] solution. Between-strain differences in Δtbody after intranasal administration of the irritants were evaluated using 6 inbred (BALB/cJ, C57BL/6J, AKR/OlaHsd, DBA/2JRccHsd, C3H/HeNHsd, and SJL/J) and 2 outbred mouse strains (SCID and CD1). BALB/cJ and SCID mice showed the most pronounced effect of intranasal administration of the xenobiotic on tbody. Thus, tbody was significantly lower after nasal administration the PtO nanoparticles than after administration of the K2[PtCl 4] solution. To study the mechanism of this decrease, we compared the respective values for Δtbody following intranasal, intravenous and peroral administration of PtO nanoparticles in Balb/c mice. Neither intravenous nor peroral administration had any effect on mouse body temperature. This fact together with data on the dynamics of the decrease in mouse body temperature following intranasal administration of PtO nanoparticles (max Δtbody ~ 80–100 min) allowed us to assume that this process is under nervous regulation. The correlation found between our data and some well-known phenotypic characteristics (phenome.jax.org) of the mouse strains used confirms this hypothesis.https://vavilov.elpub.ru/jour/article/view/433nanoparticlesintranasal administrationthermoregulationhypothermia |
| spellingShingle | D. V. Petrovskii A. V. Romashchenko S. Yu. Troitskii M. P. Moshkin Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles Вавиловский журнал генетики и селекции nanoparticles intranasal administration thermoregulation hypothermia |
| title | Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles |
| title_full | Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles |
| title_fullStr | Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles |
| title_full_unstemmed | Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles |
| title_short | Between-strain differences in hypothermic response in mice after intranasal administration of PtO nanoparticles |
| title_sort | between strain differences in hypothermic response in mice after intranasal administration of pto nanoparticles |
| topic | nanoparticles intranasal administration thermoregulation hypothermia |
| url | https://vavilov.elpub.ru/jour/article/view/433 |
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