Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis
Considering controversial data about the relationship between body size and prognosis of differentiated thyroid cancer (DTC), the current study aimed to assess the influence of body weight, body mass index (BMI), and body surface area (BSA) on DTC. We conducted a retrospective analysis of patients’...
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/2089471 |
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| author | Thaís Gomes de Melo Ligia Vera Montali da Assumpção Denise Engelbrecht Zantut-Wittmann |
| author_facet | Thaís Gomes de Melo Ligia Vera Montali da Assumpção Denise Engelbrecht Zantut-Wittmann |
| author_sort | Thaís Gomes de Melo |
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| description | Considering controversial data about the relationship between body size and prognosis of differentiated thyroid cancer (DTC), the current study aimed to assess the influence of body weight, body mass index (BMI), and body surface area (BSA) on DTC. We conducted a retrospective analysis of patients’ records from the Thyroid Cancer Unit, assessing body size measures, clinical and laboratory prognostic factors, and disease evolution. 337 patients, aged 45.95 ± 13.04 years old, with BMI of 27.87 ± 5.13 kg/m2 and BSA of 1.74 ± 0.18 m2 were enrolled. After 9.5 ± 6.9 years of follow-up, 87.29% of patients were disease-free and 12.71% had persistent disease; no patient had deceased. Patients aged <45 years old with extrathyroidal invasion tumor had greater baseline body weight and BSA than those without extrathyroidal invasion (median 79.5 kg versus 67 kg and 1.85 m2 versus 1.74 m2). Women with poorly differentiated tumor and patients aged ≥45 years old with distant metastasis presented greater weight loss during follow-up compared to patients without such characteristics (median −2 kg versus +1.5 kg and −3 kg versus +1 kg, respectively). The relationship between body size and DTC evolution was not observed. In conclusion, higher weight and BSA were associated with a greater chance of extrathyroidal tumor invasion in younger patients. Specific subgroups of patients with aggressive disease presented higher weight loss. Young patients with higher BSA should be carefully treated due to possible worse prognosis related to increased incidence of extrathyroid invasion. Findings related to tumor aggressiveness and weight loss in specific groups deserve further mechanistic studies. |
| format | Article |
| id | doaj-art-ce68625df333455fa371794f17145a48 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-ce68625df333455fa371794f17145a482025-02-03T01:26:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/20894712089471Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective AnalysisThaís Gomes de Melo0Ligia Vera Montali da Assumpção1Denise Engelbrecht Zantut-Wittmann2Division of Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, BrazilDivision of Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, BrazilDivision of Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, BrazilConsidering controversial data about the relationship between body size and prognosis of differentiated thyroid cancer (DTC), the current study aimed to assess the influence of body weight, body mass index (BMI), and body surface area (BSA) on DTC. We conducted a retrospective analysis of patients’ records from the Thyroid Cancer Unit, assessing body size measures, clinical and laboratory prognostic factors, and disease evolution. 337 patients, aged 45.95 ± 13.04 years old, with BMI of 27.87 ± 5.13 kg/m2 and BSA of 1.74 ± 0.18 m2 were enrolled. After 9.5 ± 6.9 years of follow-up, 87.29% of patients were disease-free and 12.71% had persistent disease; no patient had deceased. Patients aged <45 years old with extrathyroidal invasion tumor had greater baseline body weight and BSA than those without extrathyroidal invasion (median 79.5 kg versus 67 kg and 1.85 m2 versus 1.74 m2). Women with poorly differentiated tumor and patients aged ≥45 years old with distant metastasis presented greater weight loss during follow-up compared to patients without such characteristics (median −2 kg versus +1.5 kg and −3 kg versus +1 kg, respectively). The relationship between body size and DTC evolution was not observed. In conclusion, higher weight and BSA were associated with a greater chance of extrathyroidal tumor invasion in younger patients. Specific subgroups of patients with aggressive disease presented higher weight loss. Young patients with higher BSA should be carefully treated due to possible worse prognosis related to increased incidence of extrathyroid invasion. Findings related to tumor aggressiveness and weight loss in specific groups deserve further mechanistic studies.http://dx.doi.org/10.1155/2018/2089471 |
| spellingShingle | Thaís Gomes de Melo Ligia Vera Montali da Assumpção Denise Engelbrecht Zantut-Wittmann Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis International Journal of Endocrinology |
| title | Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis |
| title_full | Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis |
| title_fullStr | Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis |
| title_full_unstemmed | Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis |
| title_short | Interplay between Body Size Measures and Thyroid Cancer Aggressiveness: A Retrospective Analysis |
| title_sort | interplay between body size measures and thyroid cancer aggressiveness a retrospective analysis |
| url | http://dx.doi.org/10.1155/2018/2089471 |
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