Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023
Objective: Acute hemorrhagic conjunctivitis (AHC), commonly called pink eye, saw an alarming increase in incidence from July to September 2023 in different parts of India. Pink eye occurrences had reportedly increased three to four times more than in prior years, raising concerns among the community...
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Elsevier
2025-02-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034124003605 |
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| author | Nutan A. Chavan Pooja Shinde Sanjaykumar Tikute Rajlakshmi Vishwanathan Avinash R. Deoshatwar Yogesh K. Gurav Rishabh Waghchaure Nishat H. Ahmed Vannavada S. Rani Vikram Khan Aditya Kelkar Harsh H. Jain Amita Jain Mallika Lavania Babasaheb V. Tandale |
| author_facet | Nutan A. Chavan Pooja Shinde Sanjaykumar Tikute Rajlakshmi Vishwanathan Avinash R. Deoshatwar Yogesh K. Gurav Rishabh Waghchaure Nishat H. Ahmed Vannavada S. Rani Vikram Khan Aditya Kelkar Harsh H. Jain Amita Jain Mallika Lavania Babasaheb V. Tandale |
| author_sort | Nutan A. Chavan |
| collection | DOAJ |
| description | Objective: Acute hemorrhagic conjunctivitis (AHC), commonly called pink eye, saw an alarming increase in incidence from July to September 2023 in different parts of India. Pink eye occurrences had reportedly increased three to four times more than in prior years, raising concerns among the community and healthcare professionals. This study aimed to identify the aetiological agent associated with AHC in 2023, genetically characterize the agent and describe the clinical presentation. Methods: From July to September 2023, 300 ocular and throat swab samples were collected from patients with AHC across various regions of India, including Maharashtra, Daman & Diu, Delhi, Lucknow, and Hyderabad. These samples represented a diverse geographic spread of the condition. The swabs were examined for qRT-PCR analyses, to detect adenovirus and enterovirus. Following this, conserved regions within the enteroviral 5′-UTR and VP2/3 C gene were further investigated for serotype identification. Results: Enterovirus was found in 52.6 % (158 out of 300) of the patients. Among the enterovirus-positive samples, coxsackievirus-A24 was present in every positive sample. Conclusion: The rise in AHC cases in India in 2023 was attributed to the Coxsackievirus-A24 strain GIV C5. |
| format | Article |
| id | doaj-art-ce618e3243284dd291aa269baff8bfac |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-ce618e3243284dd291aa269baff8bfac2025-01-21T04:12:56ZengElsevierJournal of Infection and Public Health1876-03412025-02-01182102626Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023Nutan A. Chavan0Pooja Shinde1Sanjaykumar Tikute2Rajlakshmi Vishwanathan3Avinash R. Deoshatwar4Yogesh K. Gurav5Rishabh Waghchaure6Nishat H. Ahmed7Vannavada S. Rani8Vikram Khan9Aditya Kelkar10Harsh H. Jain11Amita Jain12Mallika Lavania13Babasaheb V. Tandale14Enteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, IndiaEnteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, IndiaEnteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, IndiaBacteriology Group, ICMR-National Institute of Virology, Sus Road, Pashan, Pune 411021, IndiaEpidemiology Group, ICMR-National Institute of Virology, Sus Road, Pashan, Pune 411021, IndiaHTA Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, IndiaEnteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, IndiaOcular Microbiology Dr. R.P. Centre, All India Institute of Medical Sciences, New Delhi 110029, IndiaDepartment of Microbiology, Osmania Medical College, Koti, Hyderabad 500095, IndiaIntegrated Disease Surveillance Programme [IDSP], UT Dadar, Nagar Haveli, Daman & Diu 396230, IndiaNational Institute of Ophthalmology, Pune 411007, IndiaNational Institute of Ophthalmology, Pune 411007, IndiaDepartment of Microbiology, King George’s Medical University, Lucknow, UP 226003, IndiaEnteric Viruses Group, ICMR-National Institute of Virology, 20-A, Dr. Ambedkar Road, Pune 411001, India; Correspondence to: Enteric Viruses Group, ICMR-National Institute of Virology, Pune, Maharashtra, India.Epidemiology Group, ICMR-National Institute of Virology, Sus Road, Pashan, Pune 411021, India; Correspondence to: Epidemiology Group, ICMR-National Institute of Virology, Pune, Maharashtra, India.Objective: Acute hemorrhagic conjunctivitis (AHC), commonly called pink eye, saw an alarming increase in incidence from July to September 2023 in different parts of India. Pink eye occurrences had reportedly increased three to four times more than in prior years, raising concerns among the community and healthcare professionals. This study aimed to identify the aetiological agent associated with AHC in 2023, genetically characterize the agent and describe the clinical presentation. Methods: From July to September 2023, 300 ocular and throat swab samples were collected from patients with AHC across various regions of India, including Maharashtra, Daman & Diu, Delhi, Lucknow, and Hyderabad. These samples represented a diverse geographic spread of the condition. The swabs were examined for qRT-PCR analyses, to detect adenovirus and enterovirus. Following this, conserved regions within the enteroviral 5′-UTR and VP2/3 C gene were further investigated for serotype identification. Results: Enterovirus was found in 52.6 % (158 out of 300) of the patients. Among the enterovirus-positive samples, coxsackievirus-A24 was present in every positive sample. Conclusion: The rise in AHC cases in India in 2023 was attributed to the Coxsackievirus-A24 strain GIV C5.http://www.sciencedirect.com/science/article/pii/S1876034124003605Acute hemorrhagic conjunctivitisEnterovirusCoxsackievirus A-24OutbreaksGenomic characterizationIndia |
| spellingShingle | Nutan A. Chavan Pooja Shinde Sanjaykumar Tikute Rajlakshmi Vishwanathan Avinash R. Deoshatwar Yogesh K. Gurav Rishabh Waghchaure Nishat H. Ahmed Vannavada S. Rani Vikram Khan Aditya Kelkar Harsh H. Jain Amita Jain Mallika Lavania Babasaheb V. Tandale Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 Journal of Infection and Public Health Acute hemorrhagic conjunctivitis Enterovirus Coxsackievirus A-24 Outbreaks Genomic characterization India |
| title | Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 |
| title_full | Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 |
| title_fullStr | Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 |
| title_full_unstemmed | Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 |
| title_short | Acute hemorrhagic conjunctivitis outbreaks associated with Coxsackievirus A-24 in India, 2023 |
| title_sort | acute hemorrhagic conjunctivitis outbreaks associated with coxsackievirus a 24 in india 2023 |
| topic | Acute hemorrhagic conjunctivitis Enterovirus Coxsackievirus A-24 Outbreaks Genomic characterization India |
| url | http://www.sciencedirect.com/science/article/pii/S1876034124003605 |
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