Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep
The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue light content from artificial sources. Although animal studies suggested blue light induced depression-like behaviors, human evidence remained l...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017196 |
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| author | Yinhan Li Xinhui Zou Ying Ma Jiaqi Cheng Xiangmin Yu Wenya Shao Fuli Zheng Zhenkun Guo Guangxia Yu Siying Wu Huangyuan Li Hong Hu |
| author_facet | Yinhan Li Xinhui Zou Ying Ma Jiaqi Cheng Xiangmin Yu Wenya Shao Fuli Zheng Zhenkun Guo Guangxia Yu Siying Wu Huangyuan Li Hong Hu |
| author_sort | Yinhan Li |
| collection | DOAJ |
| description | The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue light content from artificial sources. Although animal studies suggested blue light induced depression-like behaviors, human evidence remained limited, and the mechanisms by which blue light affects depression remained elusive. This study aimed to investigate the association between blue light exposure and depression in humans, and explored the underlying mechanisms that driving depression-like behaviors induced by blue light. Our population findings showed that the high-blue-light exposure at night was positively associated with depressive symptoms. Lactic acid was relevant to depression with Mendelian randomization analysis. Moreover, animal studies demonstrated that exposure to blue light during sleep (BLS) induced depression-like behaviors in the animals. Metabolomics and colorimetric analyses revealed elevated levels of lactic acid in the cerebrospinal fluid and lateral habenula (LHb) of rats with depression-like behaviors induced by BLS. The administration of a lactate inhibitor (Oxamate) alleviated these behaviors, along with changes in neuronal excitability, synaptic function, and morphology in the LHb. Overall, our study suggests that excessive exposure to high blue light-content artificial light at night links to increased depressive symptoms, revealing possible molecular mechanisms and prevention strategies, which are crucial for addressing environmentally related mental health issues. |
| format | Article |
| id | doaj-art-ce596ce6ba3847bda92380005028e44f |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-ce596ce6ba3847bda92380005028e44f2025-01-23T05:25:57ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117643Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleepYinhan Li0Xinhui Zou1Ying Ma2Jiaqi Cheng3Xiangmin Yu4Wenya Shao5Fuli Zheng6Zhenkun Guo7Guangxia Yu8Siying Wu9Huangyuan Li10Hong Hu11Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China; Corresponding authors at: The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China.Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China; Corresponding authors at: The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China.Department of Preventive Medicine, School of Public Health, Fujian Medical University, Fuzhou, China; The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China; Fujian Provincial Key Laboratory of Environmental Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, China; Correspondence to: Department of Preventive Medicine, School of Public Health, Fujian Medical University, Minhou County, Fuzhou 350000, China.The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue light content from artificial sources. Although animal studies suggested blue light induced depression-like behaviors, human evidence remained limited, and the mechanisms by which blue light affects depression remained elusive. This study aimed to investigate the association between blue light exposure and depression in humans, and explored the underlying mechanisms that driving depression-like behaviors induced by blue light. Our population findings showed that the high-blue-light exposure at night was positively associated with depressive symptoms. Lactic acid was relevant to depression with Mendelian randomization analysis. Moreover, animal studies demonstrated that exposure to blue light during sleep (BLS) induced depression-like behaviors in the animals. Metabolomics and colorimetric analyses revealed elevated levels of lactic acid in the cerebrospinal fluid and lateral habenula (LHb) of rats with depression-like behaviors induced by BLS. The administration of a lactate inhibitor (Oxamate) alleviated these behaviors, along with changes in neuronal excitability, synaptic function, and morphology in the LHb. Overall, our study suggests that excessive exposure to high blue light-content artificial light at night links to increased depressive symptoms, revealing possible molecular mechanisms and prevention strategies, which are crucial for addressing environmentally related mental health issues.http://www.sciencedirect.com/science/article/pii/S0147651324017196Blue lightEnvironmental exposureDepressionLateral habenulaLactic acid |
| spellingShingle | Yinhan Li Xinhui Zou Ying Ma Jiaqi Cheng Xiangmin Yu Wenya Shao Fuli Zheng Zhenkun Guo Guangxia Yu Siying Wu Huangyuan Li Hong Hu Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep Ecotoxicology and Environmental Safety Blue light Environmental exposure Depression Lateral habenula Lactic acid |
| title | Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep |
| title_full | Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep |
| title_fullStr | Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep |
| title_full_unstemmed | Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep |
| title_short | Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep |
| title_sort | lactic acid contributes to the emergence of depression like behaviors triggered by blue light exposure during sleep |
| topic | Blue light Environmental exposure Depression Lateral habenula Lactic acid |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017196 |
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