The Role of Neuroglia in the Development and Progression of Schizophrenia
Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed to explain the etiology of schizophrenia have focused largely on the dysfunction of neurotransmitters such as dopamine, serotonin and glutamate with...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/10 |
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| author | Neha S. Rawani Allen W. Chan Kathryn G. Todd Glen B. Baker Serdar M. Dursun |
| author_facet | Neha S. Rawani Allen W. Chan Kathryn G. Todd Glen B. Baker Serdar M. Dursun |
| author_sort | Neha S. Rawani |
| collection | DOAJ |
| description | Schizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed to explain the etiology of schizophrenia have focused largely on the dysfunction of neurotransmitters such as dopamine, serotonin and glutamate with their receptors, although research in the past several decades has indicated strongly that other factors are also involved and that the role of neuroglial cells in psychotic disorders including schizophrenia should be given more attention. Although glia were originally thought to be present in the brain only to support neurons in a physical, metabolic and nutritional capacity, it has become apparent that these cells have a variety of important physiological roles and that abnormalities in their function may make significant contributions to the symptoms of schizophrenia. In the present paper, we review the interactions of brain microglia, astrocytes and oligodendroglia with aspects such as transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, the gut microbiome, myelination and the blood–brain barrier that appear to affect the cause, development and treatment of schizophrenia. We also review crosstalk between microglia, astrocytes and oligodendrocytes and the effects of antipsychotics on neuroglia. Problems associated with studies on specific biomarkers for glia in schizophrenia are discussed. |
| format | Article |
| id | doaj-art-ce5865024b644007a146e2f53a605134 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-ce5865024b644007a146e2f53a6051342025-01-24T13:24:50ZengMDPI AGBiomolecules2218-273X2024-12-011511010.3390/biom15010010The Role of Neuroglia in the Development and Progression of SchizophreniaNeha S. Rawani0Allen W. Chan1Kathryn G. Todd2Glen B. Baker3Serdar M. Dursun4Neurochemical Research Unit and Bebensee Schizophrenia Research Unit, Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, CanadaNeurochemical Research Unit and Bebensee Schizophrenia Research Unit, Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, CanadaNeurochemical Research Unit and Bebensee Schizophrenia Research Unit, Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, CanadaNeurochemical Research Unit and Bebensee Schizophrenia Research Unit, Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, CanadaNeurochemical Research Unit and Bebensee Schizophrenia Research Unit, Department of Psychiatry and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2G3, CanadaSchizophrenia is a complex heterogenous disorder thought to be caused by interactions between genetic and environmental factors. The theories developed to explain the etiology of schizophrenia have focused largely on the dysfunction of neurotransmitters such as dopamine, serotonin and glutamate with their receptors, although research in the past several decades has indicated strongly that other factors are also involved and that the role of neuroglial cells in psychotic disorders including schizophrenia should be given more attention. Although glia were originally thought to be present in the brain only to support neurons in a physical, metabolic and nutritional capacity, it has become apparent that these cells have a variety of important physiological roles and that abnormalities in their function may make significant contributions to the symptoms of schizophrenia. In the present paper, we review the interactions of brain microglia, astrocytes and oligodendroglia with aspects such as transmitter dysregulation, neuro-inflammation, oxidative stress, synaptic function, the gut microbiome, myelination and the blood–brain barrier that appear to affect the cause, development and treatment of schizophrenia. We also review crosstalk between microglia, astrocytes and oligodendrocytes and the effects of antipsychotics on neuroglia. Problems associated with studies on specific biomarkers for glia in schizophrenia are discussed.https://www.mdpi.com/2218-273X/15/1/10neurogliamicrogliaastrocytesoligodendrocytestransmittersantipsychotics |
| spellingShingle | Neha S. Rawani Allen W. Chan Kathryn G. Todd Glen B. Baker Serdar M. Dursun The Role of Neuroglia in the Development and Progression of Schizophrenia Biomolecules neuroglia microglia astrocytes oligodendrocytes transmitters antipsychotics |
| title | The Role of Neuroglia in the Development and Progression of Schizophrenia |
| title_full | The Role of Neuroglia in the Development and Progression of Schizophrenia |
| title_fullStr | The Role of Neuroglia in the Development and Progression of Schizophrenia |
| title_full_unstemmed | The Role of Neuroglia in the Development and Progression of Schizophrenia |
| title_short | The Role of Neuroglia in the Development and Progression of Schizophrenia |
| title_sort | role of neuroglia in the development and progression of schizophrenia |
| topic | neuroglia microglia astrocytes oligodendrocytes transmitters antipsychotics |
| url | https://www.mdpi.com/2218-273X/15/1/10 |
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