SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate
Vaccination is the most effective intervention in reducing mortality rates due to COVID-19. Oral vaccines provide a more convenient process with a dual immune response (systemic and mucosal). Encapsulation is a strategic method that can be used to enhance the efficiency of oral vaccines. The combina...
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LPPT Universitas Gadjah Mada
2024-12-01
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| Series: | Journal of Food and Pharmaceutical Sciences |
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| Online Access: | https://jurnal.ugm.ac.id/v3/JFPS/article/view/15290/5275 |
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| author | Ni Putu Fiona Cista Dewi Ni Luh Dian Saptari Amelia Putri I Wayan Ari Sudarma Sang Ayu Putu Chika Iswari Anjani Gusti Nyoman Oka Saputra Sagung Chandra Yowani |
| author_facet | Ni Putu Fiona Cista Dewi Ni Luh Dian Saptari Amelia Putri I Wayan Ari Sudarma Sang Ayu Putu Chika Iswari Anjani Gusti Nyoman Oka Saputra Sagung Chandra Yowani |
| author_sort | Ni Putu Fiona Cista Dewi |
| collection | DOAJ |
| description | Vaccination is the most effective intervention in reducing mortality rates due to COVID-19. Oral vaccines provide a more convenient process with a dual immune response (systemic and mucosal). Encapsulation is a strategic method that can be used to enhance the efficiency of oral vaccines. The combination of chitosan and alginate can protect the drug from gastrointestinal disturbances. Our research aims to nanoencapsulate the intravenous vaccine "Inavac" using chitosan and alginate polymers into a vaccine that can be consumed orally. The optimal formulation obtained is a formula with 1.75% chitosan; 0.1% NaTPP; and 0.05% alginate, with a stirring speed of 1150 rpm and a duration of 60 minutes. Characterization results show that the nanoencapsulated COVID-19 vaccine formula is nanometer-sized with homogeneous distribution and system stability correlated with good mucoadhesive power. Good design stability is indicated by the absence of significant changes in the formula levels (p-value = 0.69), appropriate functional groups, spherical surface morphology, and the highest vaccine release in the intestine (Simulated Intestine Fluid media). Optimum Formula Oral SARS-CoV-2 vaccine with chitosan and alginate polymers has great potential to be developed so that it can be an alternative choice for the community. |
| format | Article |
| id | doaj-art-ce5612c16ab14cb4b9a5914428e9f628 |
| institution | Kabale University |
| issn | 2089-7200 2339-0948 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | LPPT Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Food and Pharmaceutical Sciences |
| spelling | doaj-art-ce5612c16ab14cb4b9a5914428e9f6282025-01-24T10:01:06ZengLPPT Universitas Gadjah MadaJournal of Food and Pharmaceutical Sciences2089-72002339-09482024-12-0112317918910.22146/jfps.15290SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and AlginateNi Putu Fiona Cista Dewi0Ni Luh Dian Saptari Amelia Putri1I Wayan Ari Sudarma2Sang Ayu Putu Chika Iswari Anjani3Gusti Nyoman Oka Saputra4Sagung Chandra Yowani5Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaDepartment of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Udayana, Jimbaran, IndonesiaVaccination is the most effective intervention in reducing mortality rates due to COVID-19. Oral vaccines provide a more convenient process with a dual immune response (systemic and mucosal). Encapsulation is a strategic method that can be used to enhance the efficiency of oral vaccines. The combination of chitosan and alginate can protect the drug from gastrointestinal disturbances. Our research aims to nanoencapsulate the intravenous vaccine "Inavac" using chitosan and alginate polymers into a vaccine that can be consumed orally. The optimal formulation obtained is a formula with 1.75% chitosan; 0.1% NaTPP; and 0.05% alginate, with a stirring speed of 1150 rpm and a duration of 60 minutes. Characterization results show that the nanoencapsulated COVID-19 vaccine formula is nanometer-sized with homogeneous distribution and system stability correlated with good mucoadhesive power. Good design stability is indicated by the absence of significant changes in the formula levels (p-value = 0.69), appropriate functional groups, spherical surface morphology, and the highest vaccine release in the intestine (Simulated Intestine Fluid media). Optimum Formula Oral SARS-CoV-2 vaccine with chitosan and alginate polymers has great potential to be developed so that it can be an alternative choice for the community.https://jurnal.ugm.ac.id/v3/JFPS/article/view/15290/5275covid-19oral vaccinenanoencapsulationchitosanalginate |
| spellingShingle | Ni Putu Fiona Cista Dewi Ni Luh Dian Saptari Amelia Putri I Wayan Ari Sudarma Sang Ayu Putu Chika Iswari Anjani Gusti Nyoman Oka Saputra Sagung Chandra Yowani SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate Journal of Food and Pharmaceutical Sciences covid-19 oral vaccine nanoencapsulation chitosan alginate |
| title | SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate |
| title_full | SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate |
| title_fullStr | SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate |
| title_full_unstemmed | SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate |
| title_short | SARS-CoV-2 Oral Vaccine Design Based on Nanoparticle Encapsulation with a Combination of Chitosan and Alginate |
| title_sort | sars cov 2 oral vaccine design based on nanoparticle encapsulation with a combination of chitosan and alginate |
| topic | covid-19 oral vaccine nanoencapsulation chitosan alginate |
| url | https://jurnal.ugm.ac.id/v3/JFPS/article/view/15290/5275 |
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