Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?
The gut microbiota refers to the trillions of microorganisms residing in the intestine and is integral in multiple physiological processes of the host. Recent research has shown that gut bacteria play a role in metabolic disorders such as obesity, diabetes, and cardiovascular diseases. The mechanism...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/879151 |
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| author | Kristina Harris Amira Kassis Geneviève Major Chieh J. Chou |
| author_facet | Kristina Harris Amira Kassis Geneviève Major Chieh J. Chou |
| author_sort | Kristina Harris |
| collection | DOAJ |
| description | The gut microbiota refers to the trillions of microorganisms residing in the intestine and is integral in multiple physiological processes of the host. Recent research has shown that gut bacteria play a role in metabolic disorders such as obesity, diabetes, and cardiovascular diseases. The mechanisms by which the gut microbiota affects metabolic diseases are by two major routes: (1) the innate immune response to the structural components of bacteria (e.g., lipopolysaccharide) resulting in inflammation and (2) bacterial metabolites of dietary compounds (e.g., SCFA from fiber), which have biological activities that regulate host functions. Gut microbiota has evolved with humans as a mutualistic partner, but dysbiosis in a form of altered gut metagenome and collected microbial activities, in combination with classic genetic and environmental factors, may promote the development of metabolic disorders. This paper reviews the available literature about the gut microbiota and aforementioned metabolic disorders and reveals the gaps in knowledge for future study. |
| format | Article |
| id | doaj-art-ce4cdb6c6b8c4d918d1c00e0a3fee582 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-ce4cdb6c6b8c4d918d1c00e0a3fee5822025-02-03T01:25:56ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/879151879151Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?Kristina Harris0Amira Kassis1Geneviève Major2Chieh J. Chou3Department of Nutritional Sciences, The Penn State University, 110 Chandlee Laboratory University Park, PA 16802, USANutrition and Health Department, Nestlé Research Center, Route du Jorat 57, Lausanne 26, CH-1000, SwitzerlandNutrition and Health Department, Nestlé Research Center, Route du Jorat 57, Lausanne 26, CH-1000, SwitzerlandNutrition and Health Department, Nestlé Research Center, Route du Jorat 57, Lausanne 26, CH-1000, SwitzerlandThe gut microbiota refers to the trillions of microorganisms residing in the intestine and is integral in multiple physiological processes of the host. Recent research has shown that gut bacteria play a role in metabolic disorders such as obesity, diabetes, and cardiovascular diseases. The mechanisms by which the gut microbiota affects metabolic diseases are by two major routes: (1) the innate immune response to the structural components of bacteria (e.g., lipopolysaccharide) resulting in inflammation and (2) bacterial metabolites of dietary compounds (e.g., SCFA from fiber), which have biological activities that regulate host functions. Gut microbiota has evolved with humans as a mutualistic partner, but dysbiosis in a form of altered gut metagenome and collected microbial activities, in combination with classic genetic and environmental factors, may promote the development of metabolic disorders. This paper reviews the available literature about the gut microbiota and aforementioned metabolic disorders and reveals the gaps in knowledge for future study.http://dx.doi.org/10.1155/2012/879151 |
| spellingShingle | Kristina Harris Amira Kassis Geneviève Major Chieh J. Chou Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? Journal of Obesity |
| title | Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? |
| title_full | Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? |
| title_fullStr | Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? |
| title_full_unstemmed | Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? |
| title_short | Is the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders? |
| title_sort | is the gut microbiota a new factor contributing to obesity and its metabolic disorders |
| url | http://dx.doi.org/10.1155/2012/879151 |
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