ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure)
Introduction Functional constipation is common in childhood, with chronicity leading to a significant impact on patients and their families. There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an...
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BMJ Publishing Group
2025-02-01
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| Series: | BMJ Paediatrics Open |
| Online Access: | https://bmjpaedsopen.bmj.com/content/9/1/e003161.full |
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| author | Marc A Benninga Morris Gordon Nikhil Thapar Osvaldo Borrelli Vassiliki Sinopoulou Merit Tabbers Anil Darbari Julie Khlevner Anna de Geus Marcin Banasiuk Mary Boruta Dawn Dore-Stites Michelle Gould Juliette Hawa Kirsten Brooke Jones Alexandra Kilgore Hayat Mousa Samuel Nurko |
| author_facet | Marc A Benninga Morris Gordon Nikhil Thapar Osvaldo Borrelli Vassiliki Sinopoulou Merit Tabbers Anil Darbari Julie Khlevner Anna de Geus Marcin Banasiuk Mary Boruta Dawn Dore-Stites Michelle Gould Juliette Hawa Kirsten Brooke Jones Alexandra Kilgore Hayat Mousa Samuel Nurko |
| author_sort | Marc A Benninga |
| collection | DOAJ |
| description | Introduction Functional constipation is common in childhood, with chronicity leading to a significant impact on patients and their families. There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. We present the prospectively agreed operating procedure and technical review protocol in this manuscript.Methods ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) will be used for all phases of this guideline development. The Guideline Development Group is formed by paediatric gastroenterologists from both the ESPGHAN as well as the NASPGHAN. A prospective exercise will agree on key outcomes, thresholds of magnitude that are significant at small, moderate and large levels. Systematic evidence searches, selection, extraction, appraisal and analysis will be performed following Cochrane guidance and GRADE guidance for objectively agreeing the certainty of findings. Additional use of network meta-analysis will identify areas of broad triangulation in the evidence. Summary of findings tables will be produced and inform evidence to decision frameworks. These will guide GRADE recommendations with voting to reach a consensus. |
| format | Article |
| id | doaj-art-ce404e25abc240148505e413009ae1ec |
| institution | Kabale University |
| issn | 2399-9772 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Paediatrics Open |
| spelling | doaj-art-ce404e25abc240148505e413009ae1ec2025-02-04T17:30:09ZengBMJ Publishing GroupBMJ Paediatrics Open2399-97722025-02-019110.1136/bmjpo-2024-003161ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure)Marc A Benninga0Morris Gordon1Nikhil Thapar2Osvaldo Borrelli3Vassiliki Sinopoulou4Merit Tabbers5Anil Darbari6Julie Khlevner7Anna de Geus8Marcin Banasiuk9Mary Boruta10Dawn Dore-Stites11Michelle Gould12Juliette Hawa13Kirsten Brooke Jones14Alexandra Kilgore15Hayat Mousa16Samuel Nurko17Department of Paediatric Gastroenterology, Emma Childrens` Hospital UMC, Amsterdam, The NetherlandsUniversity of Central Lancashire, Preston, UKQueensland Children`s Hospital, South Brisbane, Queensland, AustraliaGreat Ormond Street Hospital for Children, London, London, UKUniversity of Central Lancashire, Preston, Lancashire, UKUniversity of Amsterdam, Amsterdam, The NetherlandsChildren`s National, Washington, District of Columbia, USAPediatric Gastroenterology, Hepatology and Nutrition, New York-Presbyterian Morgan Stanley Children`s Hospital, New York, New York, USAPeadiatric Gastroenterology and Nutrition, Emma Children’s Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsDepartment of Paediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warszawa, PolandDepartment of Pediatrics, Duke University, Durham, North Carolina, USAPediatric Psychology, Michigan Medicine, Ann Arbor, Michigan, USAGastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, Toronto, Ontario, CanadaPhysical Therapy, Children’s Hospital Colorado, Aurora, Colorado, USAClinical nutrition and Lactation, Nationwide Children’s Hospital, Columbus, Ohio, USADepartment of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USAGastroenterology, The Children`s Hospital of Philadelphia, Philadelphia, Pennsylvania, USABoston Children`s Hospital, Boston, Massachusetts, USAIntroduction Functional constipation is common in childhood, with chronicity leading to a significant impact on patients and their families. There is a significant range of therapies available to healthcare professionals for this condition, with many novel or recently studied. There is a need for an update to the joint European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guidelines last released in 2014. We present the prospectively agreed operating procedure and technical review protocol in this manuscript.Methods ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) will be used for all phases of this guideline development. The Guideline Development Group is formed by paediatric gastroenterologists from both the ESPGHAN as well as the NASPGHAN. A prospective exercise will agree on key outcomes, thresholds of magnitude that are significant at small, moderate and large levels. Systematic evidence searches, selection, extraction, appraisal and analysis will be performed following Cochrane guidance and GRADE guidance for objectively agreeing the certainty of findings. Additional use of network meta-analysis will identify areas of broad triangulation in the evidence. Summary of findings tables will be produced and inform evidence to decision frameworks. These will guide GRADE recommendations with voting to reach a consensus.https://bmjpaedsopen.bmj.com/content/9/1/e003161.full |
| spellingShingle | Marc A Benninga Morris Gordon Nikhil Thapar Osvaldo Borrelli Vassiliki Sinopoulou Merit Tabbers Anil Darbari Julie Khlevner Anna de Geus Marcin Banasiuk Mary Boruta Dawn Dore-Stites Michelle Gould Juliette Hawa Kirsten Brooke Jones Alexandra Kilgore Hayat Mousa Samuel Nurko ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) BMJ Paediatrics Open |
| title | ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) |
| title_full | ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) |
| title_fullStr | ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) |
| title_full_unstemmed | ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) |
| title_short | ESPGHAN and NASPGHAN 2024 protocol for paediatric functional constipation treatment guidelines (standard operating procedure) |
| title_sort | espghan and naspghan 2024 protocol for paediatric functional constipation treatment guidelines standard operating procedure |
| url | https://bmjpaedsopen.bmj.com/content/9/1/e003161.full |
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