Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA
Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid from Isatis. Two novel FeII and CoII complexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetr...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2016/5075847 |
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| author | Yi-ning Zhong Yan Zhang Yun-qiong Gu Shi-yun Wu Wen-ying Shen Ming-xiong Tan |
| author_facet | Yi-ning Zhong Yan Zhang Yun-qiong Gu Shi-yun Wu Wen-ying Shen Ming-xiong Tan |
| author_sort | Yi-ning Zhong |
| collection | DOAJ |
| description | Tryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid from Isatis. Two novel FeII and CoII complexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA. This study may potentially serve as the basis of future rational design of metal-based drugs from natural products that target the G-quadruplex DNA. |
| format | Article |
| id | doaj-art-ce371f30d4b546d9b2a2f82d68934e69 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-ce371f30d4b546d9b2a2f82d68934e692025-02-03T01:03:49ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2016-01-01201610.1155/2016/50758475075847Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNAYi-ning Zhong0Yan Zhang1Yun-qiong Gu2Shi-yun Wu3Wen-ying Shen4Ming-xiong Tan5College of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, ChinaCollege of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, ChinaGuangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, ChinaCollege of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, ChinaGuangxi Key Laboratory for Agricultural Resources Chemistry and Efficient Utilization (Cultivation Base), Yulin Normal University, Yulin, Guangxi 537000, ChinaCollege of Pharmacy of Guangxi University of Chinese Medicine, Nanning, Guangxi 530299, ChinaTryptanthrin is one of the most important members of indoloquinoline alkaloids. We obtained this alkaloid from Isatis. Two novel FeII and CoII complexes of tryptanthrin were first synthesized. Single-crystal X-ray diffraction analyses show that these complexes display distorted four-coordinated tetrahedron geometry via two heterocyclic nitrogen and oxygen atoms from tryptanthrin ligand. Binding with G-quadruplex DNA properties revealed that both complexes were found to exhibit significant interaction with G-quadruplex DNA. This study may potentially serve as the basis of future rational design of metal-based drugs from natural products that target the G-quadruplex DNA.http://dx.doi.org/10.1155/2016/5075847 |
| spellingShingle | Yi-ning Zhong Yan Zhang Yun-qiong Gu Shi-yun Wu Wen-ying Shen Ming-xiong Tan Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA Bioinorganic Chemistry and Applications |
| title | Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA |
| title_full | Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA |
| title_fullStr | Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA |
| title_full_unstemmed | Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA |
| title_short | Novel FeII and CoII Complexes of Natural Product Tryptanthrin: Synthesis and Binding with G-Quadruplex DNA |
| title_sort | novel feii and coii complexes of natural product tryptanthrin synthesis and binding with g quadruplex dna |
| url | http://dx.doi.org/10.1155/2016/5075847 |
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