IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis
Allergic rhinitis (AR) is a chronic upper airway immune-inflammation response mediated by immunoglobulin E (IgE) to allergens and can seriously affect the quality of life and work efficiency. Previous studies have shown that interleukin-1β (IL-1β) acts as a key cytokine to participate in and promote...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/1265449 |
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| _version_ | 1832546767116173312 |
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| author | Han-Rui Wang Shi-Zhuang Wei Xiao-Yu Song Yao Wang Wen-Bin Zhang Chao Ren Ya-Kui Mou Xi-Cheng Song |
| author_facet | Han-Rui Wang Shi-Zhuang Wei Xiao-Yu Song Yao Wang Wen-Bin Zhang Chao Ren Ya-Kui Mou Xi-Cheng Song |
| author_sort | Han-Rui Wang |
| collection | DOAJ |
| description | Allergic rhinitis (AR) is a chronic upper airway immune-inflammation response mediated by immunoglobulin E (IgE) to allergens and can seriously affect the quality of life and work efficiency. Previous studies have shown that interleukin-1β (IL-1β) acts as a key cytokine to participate in and promote the occurrence and development of allergic diseases. It has been proposed that IL-1β may be a potential biomarker of AR. However, its definitive role and potential mechanism in AR have not been fully elucidated, and the clinical sample collection and detection methods were inconsistent among different studies, which have limited the use of IL-1β as a clinical diagnosis and treatment marker for AR. This article systematically summarizes the research advances in the roles of IL-1β in allergic diseases, focusing on the changes of IL-1β in AR and the possible interventions. In addition, based on the findings by our team, we provided new insights into the use of IL-1β in AR diagnosis and treatment, in an attempt to further promote the clinical application of IL-1β in AR and other allergic diseases. |
| format | Article |
| id | doaj-art-ce351fcf32f640518a278d43080aa219 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ce351fcf32f640518a278d43080aa2192025-02-03T06:47:16ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/1265449IL-1β and Allergy: Focusing on Its Role in Allergic RhinitisHan-Rui Wang0Shi-Zhuang Wei1Xiao-Yu Song2Yao Wang3Wen-Bin Zhang4Chao Ren5Ya-Kui Mou6Xi-Cheng Song7Department of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyDepartment of OtorhinolaryngologyAllergic rhinitis (AR) is a chronic upper airway immune-inflammation response mediated by immunoglobulin E (IgE) to allergens and can seriously affect the quality of life and work efficiency. Previous studies have shown that interleukin-1β (IL-1β) acts as a key cytokine to participate in and promote the occurrence and development of allergic diseases. It has been proposed that IL-1β may be a potential biomarker of AR. However, its definitive role and potential mechanism in AR have not been fully elucidated, and the clinical sample collection and detection methods were inconsistent among different studies, which have limited the use of IL-1β as a clinical diagnosis and treatment marker for AR. This article systematically summarizes the research advances in the roles of IL-1β in allergic diseases, focusing on the changes of IL-1β in AR and the possible interventions. In addition, based on the findings by our team, we provided new insights into the use of IL-1β in AR diagnosis and treatment, in an attempt to further promote the clinical application of IL-1β in AR and other allergic diseases.http://dx.doi.org/10.1155/2023/1265449 |
| spellingShingle | Han-Rui Wang Shi-Zhuang Wei Xiao-Yu Song Yao Wang Wen-Bin Zhang Chao Ren Ya-Kui Mou Xi-Cheng Song IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis Mediators of Inflammation |
| title | IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis |
| title_full | IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis |
| title_fullStr | IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis |
| title_full_unstemmed | IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis |
| title_short | IL-1β and Allergy: Focusing on Its Role in Allergic Rhinitis |
| title_sort | il 1β and allergy focusing on its role in allergic rhinitis |
| url | http://dx.doi.org/10.1155/2023/1265449 |
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